Literature DB >> 30910572

Mitochondrial genome variations in idiopathic dilated cardiomyopathy.

Periyasamy Govindaraj1, Bindu Rani2, Pandarisamy Sundaravadivel3, Ayyasamy Vanniarajan3, K P Indumathi4, Nahid Akthar Khan3, Perundurai S Dhandapany5, Deepa Selvi Rani3, Rakesh Tamang3, Ajay Bahl6, Calambur Narasimhan7, Dharma Rakshak8, Andiappan Rathinavel9, Kumpati Premkumar10, Madhu Khullar2, Kumarasamy Thangaraj11.   

Abstract

Idiopathic dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. The aim of this study was to assess the role of mitochondrial DNA (mtDNA) variations and haplogroups in Indian DCM patients. Whole mtDNA analysis of 221 DCM patients revealed 48 novel, 42 disease-associated and 97 private variations. The frequency of reported variations associated with hearing impairment, DEAF, SNHL and LHON are significantly high in DCM patients than controls. Haplogroups H and HV were over represented in DCM than controls. Functional analysis of two private variations (m.8812A>G & m.10320G>A) showed decrease in mitochondrial functions, suggesting the role of mtDNA variations in DCM.
Copyright © 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Entities:  

Keywords:  Cybrids; DCM; Haplogroups; Mitochondria; Mutations; mtDNA

Mesh：

Substances：

Year:  2019        PMID： 30910572     DOI： 10.1016/j.mito.2019.03.003

Source DB:  PubMed          Journal:  Mitochondrion        ISSN： 1567-7249            Impact factor:   4.160


  7 in total

1.  Easing US restrictions on mitochondrial replacement therapy would protect research interests but grease the slippery slope.

Authors:  David L Keefe
Journal:  J Assist Reprod Genet       Date:  2019-08-28       Impact factor: 3.412

2.  Machine learning-based classification and diagnosis of clinical cardiomyopathies.

Authors:  Ahmad Alimadadi; Ishan Manandhar; Sachin Aryal; Patricia B Munroe; Bina Joe; Xi Cheng
Journal:  Physiol Genomics       Date:  2020-08-03       Impact factor: 3.107

3.  Effect of mtDNA depletion from C6 glioma cells and characteristics of the generated C6ρ0 cells.

Authors:  Youcai Jin; Guangxiang Luan; Ji Li; Honglun Wang; Zhenhua Wang; Bo Bai
Journal:  Mol Med Rep       Date:  2021-02-12       Impact factor: 2.952

4.  Novel Mutations in β-MYH7 Gene in Indian Patients With Dilated Cardiomyopathy.

Authors:  Deepa Selvi Rani; Archana Vijaya Kumar; Pratibha Nallari; Katakam Sampathkumar; Perundurai S Dhandapany; Calambur Narasimhan; Andiappan Rathinavel; Kumarasamy Thangaraj
Journal:  CJC Open       Date:  2021-08-08

5.  Circulating circRNA as biomarkers for dilated cardiomyopathy etiology.

Authors:  Marina C Costa; Maria Calderon-Dominguez; Alipio Mangas; Oscar Campuzano; Georgia Sarquella-Brugada; Mónica Ramos; Maribel Quezada-Feijoo; José Manuel García Pinilla; Ainhoa Robles-Mezcua; Galan Del Aguila Pacheco-Cruz; Thalia Belmonte; Francisco J Enguita; Rocío Toro
Journal:  J Mol Med (Berl)       Date:  2021-09-08       Impact factor: 4.599

6.  Molecular studies in familial dilated cardiomyopathy - A pilot study.

Authors:  Vyom Mori; J P S Sawhney; I C Verma; Ashwani Mehta; Renu Saxena; Rajiv Passey; Arun Mohanty; Bhuwanesh Kandpal; B S Vivek; Manish Sharma; Ashish Kumar Jain; Dipak Katare
Journal:  Int J Cardiol Heart Vasc       Date:  2022-04-11

Review 7.  Molecular Epidemiology of Mitochondrial Cardiomyopathy: A Search Among Mitochondrial and Nuclear Genes.

Authors:  Cristina Mazzaccara; Bruno Mirra; Ferdinando Barretta; Martina Caiazza; Barbara Lombardo; Olga Scudiero; Nadia Tinto; Giuseppe Limongelli; Giulia Frisso
Journal:  Int J Mol Sci       Date:  2021-05-27       Impact factor: 6.208
  7 in total

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