Yuanyuan Zhong1, Li Ke2, Wu Qiong2, Fengyang Liu2. 1. The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laborary of Ophthalmology and Chongqing Eye Institute, Chongqing, PR China. Electronic address: towelface2017@163.com. 2. The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laborary of Ophthalmology and Chongqing Eye Institute, Chongqing, PR China.
Abstract
PURPOSE: To investigate the effect of overnight orthokeratology (OK) lens wear on axial growth in anisometropic children. METHODS: The study involved 17 males and 12 females with an average age of 11.4 ± 2.9 years. Cycloplegic spherical equivalent error (SER) was -0.50D to -6.00D, and anisometropia ≥1.00D. The eyes with greater myopia were assigned to the G eye group and the fellow eyes with less myopia to the L eye group. All eyes were fitted with OK lenses. Axial length (AL) was measured at the beginning of the study and at 6-, 12-, 18-, and 24-month follow-up visits. Refractive error was measured at the beginning and at the 24-month visit. Linear mixed model analysis was used to evaluate the effect of time, group, and time*group on axial growth. Paired t test was used to compare the myopia increase over 24 months between the two groups. RESULTS: The mean baseline AL was 25.06 ± 0.61 mm for the G eyes and 24.48 ± 0.61 mm for the L eyes. After 24 months, AL had increased by 0.31 ± 0.23 mm in the G eye group and by 0.41 ± 0.31 mm in the L eye group. Axial growth of the L eyes was significantly greater than that of the G eyes (p = 0.006). The mean baseline myopia of the G eye and the L eye was -3.62 ± 1.27D [-5.75D to -1.75D] and -1.93 ± 1.02D [-4.00D to -0.50D] respectively. At 24 months, the increase in myopia in the G eyes was significantly less than that in the L eyes (-0.84 ± 0.63D vs, -1.21 ± 0.89D, p < 0.001). CONCLUSIONS: In anisometropic children who wore OK lenses, axial growth was greater in the eye with less baseline myopia than in the fellow eye with greater baseline myopia after 2 years.
RCT Entities:
PURPOSE: To investigate the effect of overnight orthokeratology (OK) lens wear on axial growth in anisometropic children. METHODS: The study involved 17 males and 12 females with an average age of 11.4 ± 2.9 years. Cycloplegic spherical equivalent error (SER) was -0.50D to -6.00D, and anisometropia ≥1.00D. The eyes with greater myopia were assigned to the G eye group and the fellow eyes with less myopia to the L eye group. All eyes were fitted with OK lenses. Axial length (AL) was measured at the beginning of the study and at 6-, 12-, 18-, and 24-month follow-up visits. Refractive error was measured at the beginning and at the 24-month visit. Linear mixed model analysis was used to evaluate the effect of time, group, and time*group on axial growth. Paired t test was used to compare the myopia increase over 24 months between the two groups. RESULTS: The mean baseline AL was 25.06 ± 0.61 mm for the G eyes and 24.48 ± 0.61 mm for the L eyes. After 24 months, AL had increased by 0.31 ± 0.23 mm in the G eye group and by 0.41 ± 0.31 mm in the L eye group. Axial growth of the L eyes was significantly greater than that of the G eyes (p = 0.006). The mean baseline myopia of the G eye and the L eye was -3.62 ± 1.27D [-5.75D to -1.75D] and -1.93 ± 1.02D [-4.00D to -0.50D] respectively. At 24 months, the increase in myopia in the G eyes was significantly less than that in the L eyes (-0.84 ± 0.63D vs, -1.21 ± 0.89D, p < 0.001). CONCLUSIONS: In anisometropic children who wore OK lenses, axial growth was greater in the eye with less baseline myopia than in the fellow eye with greater baseline myopia after 2 years.