Egbert Matthé1, Peggy Eulitz1, Olga Furashova2. 1. Department of Ophthalmology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; and. 2. Department of Ophthalmology, Städtisches Klinikum Chemnitz gGmbH, Chemnitz, Germany.
Abstract
PURPOSE: To compare changes in thickness of separate retinal layers between acute central and branch retinal artery occlusion (RAO) regarding the severity grade of retinal ischemia using spectral-domain optical coherence tomography. METHODS: Design: retrospective, observational case-control series. SETTING: institutional. PATIENTS: 114 patients with acute RAO. Examinations were conducted with spectral-domain optical coherence tomography at the first visit (baseline). OBSERVATIONS: RAO was categorized as branch (43 patients) or central RAO (71 patients) clinically. Retinal artery occlusion was categorized into the 3 grades "incomplete," "subtotal," and "total," based on optical coherence tomography findings. Thickness of several retinal layers was evaluated on spectral-domain optical coherence tomography images. Obtained data were compared between the 3 grades and between central and branch RAO. The contralateral eyes were used as controls. MAIN OUTCOME MEASURES: thickness of selected retinal layers. RESULTS: Thickness of selected inner retinal layers and central foveal thickness increased statistically significant according to the severity grade (healthy = incomplete < subtotal < total). In each severity grade, there was no significant difference in retinal layers' thickness between branch and central RAO, except for central foveal thickness. CONCLUSION: Thickness increase of selected retinal layers follows-except for central foveal thickness-the same pattern in central and branch RAO. Retinal layers' thickness increases significantly with the higher ischemia grade in both central and branch RAO.
PURPOSE: To compare changes in thickness of separate retinal layers between acute central and branch retinal artery occlusion (RAO) regarding the severity grade of retinal ischemia using spectral-domain optical coherence tomography. METHODS: Design: retrospective, observational case-control series. SETTING: institutional. PATIENTS: 114 patients with acute RAO. Examinations were conducted with spectral-domain optical coherence tomography at the first visit (baseline). OBSERVATIONS: RAO was categorized as branch (43 patients) or central RAO (71 patients) clinically. Retinal artery occlusion was categorized into the 3 grades "incomplete," "subtotal," and "total," based on optical coherence tomography findings. Thickness of several retinal layers was evaluated on spectral-domain optical coherence tomography images. Obtained data were compared between the 3 grades and between central and branch RAO. The contralateral eyes were used as controls. MAIN OUTCOME MEASURES: thickness of selected retinal layers. RESULTS: Thickness of selected inner retinal layers and central foveal thickness increased statistically significant according to the severity grade (healthy = incomplete < subtotal < total). In each severity grade, there was no significant difference in retinal layers' thickness between branch and central RAO, except for central foveal thickness. CONCLUSION: Thickness increase of selected retinal layers follows-except for central foveal thickness-the same pattern in central and branch RAO. Retinal layers' thickness increases significantly with the higher ischemia grade in both central and branch RAO.
Authors: Daniel A Wenzel; Sven Poli; Maria Casagrande; Vasyl Druchkiv; Martin S Spitzer; Karl Ulrich Bartz-Schmidt; Carsten Grohmann; Maximilian Schultheiss Journal: Front Med (Lausanne) Date: 2022-07-06