| Literature DB >> 30908032 |
Jessica Wahsner1, Pauline Désogère1, Eric Abston2, Katherine A Graham-O'Regan1, Junfeng Wang1, Nicholas J Rotile1, Markus D Schirmer3, Diêgo Dos Santos Ferreira1, Jingyi Sui1, Bryan C Fuchs4, Michael Lanuti2, Peter Caravan1.
Abstract
Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated ( R2 = 0.98) with the concentration of lung allysine.Entities:
Year: 2019 PMID： 30908032 PMCID： PMC6494104 DOI： 10.1021/jacs.8b12342
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419