Literature DB >> 30907628

Structure-based drug discovery by targeting N-glycan biosynthesis, dolichyl-phosphate N-acetylglucosaminephosphotransferase.

Michio Kurosu1.   

Abstract

Entities:  

Keywords:  DPAGT1; anticancer drugs; co-crystal structures; inhibitors; structure-based drug design

Mesh：

Substances：

Year:  2019        PMID： 30907628      PMCID： PMC6587103          DOI： 10.4155/fmc-2018-0405

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  18 in total

1.  Tunicamycin potentiates paclitaxel-induced apoptosis through inhibition of PI3K/AKT and MAPK pathways in breast cancer.

Authors:  Shengshi Huang; Di Wang; Shu Zhang; Xiaoyan Huang; Dandan Wang; Muhammad Ijaz; Yikang Shi
Journal:  Cancer Chemother Pharmacol       Date:  2017-08-04       Impact factor: 3.333

2.  Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells.

Authors:  Babak Nami; Huseyin Donmez; Nadir Kocak
Journal:  Exp Toxicol Pathol       Date:  2016-06-24

3.  Inhibition of N-Glycosylation towards Novel Anti-Cancer Chemotherapeutics.

Authors:  Michio Kurosu
Journal:  J Mol Pharm Org Process Res       Date:  2018-01-12

4.  Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors.

Authors:  Katsuhiko Mitachi; Shajila Siricilla; Dong Yang; Ying Kong; Karolina Skorupinska-Tudek; Ewa Swiezewska; Scott G Franzblau; Michio Kurosu
Journal:  Anal Biochem       Date:  2016-08-13       Impact factor: 3.365

5.  Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions.

Authors:  Mihai Nita-Lazar; Ivan Rebustini; Janice Walker; Maria A Kukuruzinska
Journal:  Exp Cell Res       Date:  2010-02-13       Impact factor: 3.905

Review 6.  Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

Authors:  A Jeanes; C J Gottardi; A S Yap
Journal:  Oncogene       Date:  2008-11-24       Impact factor: 9.867

7.  Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma.

Authors:  Helei Hou; Hefen Sun; Ping Lu; Chao Ge; Lixing Zhang; Hong Li; Fangyu Zhao; Hua Tian; Lin Zhang; Taoyang Chen; Ming Yao; Jinjun Li
Journal:  Mol Cancer Ther       Date:  2013-10-15       Impact factor: 6.261

8.  Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates.

Authors:  Katsiaryna Belaya; Sarah Finlayson; Clarke R Slater; Judith Cossins; Wei Wei Liu; Susan Maxwell; Simon J McGowan; Siarhei Maslau; Stephen R F Twigg; Timothy J Walls; Samuel I Pascual Pascual; Jacqueline Palace; David Beeson
Journal:  Am J Hum Genet       Date:  2012-06-27       Impact factor: 11.025

9.  Novel FR-900493 Analogues That Inhibit the Outgrowth of Clostridium difficile Spores.

Authors:  Katsuhiko Mitachi; Hyun Gi Yun; Sara M Kurosu; Shakiba Eslamimehr; Maddie R Lemieux; Lada Klaić; William M Clemons; Michio Kurosu
Journal:  ACS Omega       Date:  2018-02-09

10.  Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

Authors:  Yin Yao Dong; Hua Wang; Ashley C W Pike; Stephen A Cochrane; Sadra Hamedzadeh; Filip J Wyszyński; Simon R Bushell; Sylvain F Royer; David A Widdick; Andaleeb Sajid; Helena I Boshoff; Yumi Park; Ricardo Lucas; Wei-Min Liu; Seung Seo Lee; Takuya Machida; Leanne Minall; Shahid Mehmood; Katsiaryna Belaya; Wei-Wei Liu; Amy Chu; Leela Shrestha; Shubhashish M M Mukhopadhyay; Claire Strain-Damerell; Rod Chalk; Nicola A Burgess-Brown; Mervyn J Bibb; Clifton E Barry Iii; Carol V Robinson; David Beeson; Benjamin G Davis; Elisabeth P Carpenter
Journal:  Cell       Date:  2018-11-01       Impact factor: 41.582
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  5 in total

1.  DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors.

Authors:  Katsuhiko Mitachi; Rita G Kansal; Kirk E Hevener; Cody D Gillman; Syed M Hussain; Hyun Gi Yun; Gustavo A Miranda-Carboni; Evan S Glazer; William M Clemons; Michio Kurosu
Journal:  J Med Chem       Date:  2020-09-18       Impact factor: 7.446

2.  Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis.

Authors:  Nada Lelovic; Katsuhiko Mitachi; Junshu Yang; Maddie R Lemieux; Yinduo Ji; Michio Kurosu
Journal:  J Antibiot (Tokyo)       Date:  2020-05-29       Impact factor: 2.649

3.  Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor.

Authors:  Katsuhiko Mitachi; David Mingle; Wendy Effah; Antonio Sánchez-Ruiz; Kirk E Hevener; Ramesh Narayanan; William M Clemons; Francisco Sarabia; Michio Kurosu
Journal:  Angew Chem Int Ed Engl       Date:  2022-06-10       Impact factor: 16.823

4.  A Convenient Protecting Group for Uridine Ureido Nitrogen: (4,4'-Bisfluorophenyl)methoxymethyl group.

Authors:  Katsuhiko Mitachi; David Mingle; Michio Kurosu
Journal:  Synthesis (Stuttg)       Date:  2021-03-25       Impact factor: 2.969

5.  Antibacterial Activity of Pharmaceutical-Grade Rose Bengal: An Application of a Synthetic Dye in Antibacterial Therapies.

Authors:  Michio Kurosu; Katsuhiko Mitachi; Junshu Yang; Edward V Pershing; Bruce D Horowitz; Eric A Wachter; John W Lacey; Yinduo Ji; Dominic J Rodrigues
Journal:  Molecules       Date:  2022-01-05       Impact factor: 4.411
  5 in total

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