| Literature DB >> 3090738 |
R C Srivastava, P P Dwivedi, J R Behari, M Athar.
Abstract
The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA. A possible correlation between the toxicity and molecular structure of the compounds is discussed.Entities:
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Year: 1986 PMID： 3090738 DOI： 10.1016/0378-4274(86)90046-9
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372