Sreeram V Ramagopalan1, Robert Carroll1, Maria Ulvestad2, Faisal Mehmud3, Raza Alikhan4. 1. Centre for Observational Research & Data Sciences, Bristol-Myers Squibb, Uxbridge UB8 1DH, UK. 2. Medical Department, Bristol-Myers Squibb, 1366 Lysaker, Norway. 3. Medical Department, Bristol-Myers Squibb, Uxbridge UB8 1DH, UK. 4. Haemophilia & Thrombosis Centre, University Hospital Wales, Cardiff, UK.
Abstract
Aim: Venous thromboembolism (VTE), which comprises deep vein thrombosis and pulmonary embolism, poses a global disease burden. Vitamin K antagonists have traditionally been the mainstay of treatment; however, the non-vitamin K oral anticoagulants (NOACs) are emerging as an alternative. The relative use of these treatment classes in the real world is unknown. Patients & methods: We performed a retrospective study using data from the UK Clinical Practice Research Datalink to understand VTE treatment patterns. Results: NOACs have unseated vitamin K antagonist as the main form of VTE patient treatment in England. Conclusion: The data highlight how comfortable physicians have become in using NOACs to treat VTE in England and it is likely that the increasing use of NOACs will continue.
Aim: Venous thromboembolism (VTE), which comprises deep vein thrombosis and pulmonary embolism, poses a global disease burden. Vitamin K antagonists have traditionally been the mainstay of treatment; however, the non-vitamin K oral anticoagulants (NOACs) are emerging as an alternative. The relative use of these treatment classes in the real world is unknown. Patients & methods: We performed a retrospective study using data from the UK Clinical Practice Research Datalink to understand VTE treatment patterns. Results:NOACs have unseated vitamin K antagonist as the main form of VTEpatient treatment in England. Conclusion: The data highlight how comfortable physicians have become in using NOACs to treat VTE in England and it is likely that the increasing use of NOACs will continue.
Entities:
Keywords:
Clinical Practice Research Datalink; England; database; deep vein thrombosis; epidemiology; hospital episode statistics; oral anticoagulant; pulmonary embolism; treatment; venous thromboembolism