Literature DB >> 30906732

Skull Base Mucormycosis in an Immunocompetent Patient: A Case Report and Literature Review.

N Vishnu Swaroop Reddy1, Raja Sekharam Natti1, T Radha1, Manoj Sharma1, Murali Chintham1.   

Abstract

To demonstrate the affection of skull base by mucormycosis in an immunocompetent individual. Mucormycosis is an opportunistic infection principally seen in immunocompromised individuals, but recently being increasingly recognized in otherwise healthy individuals. Skull base involvement secondary to otogenic nidus, mimicking otitis media was rarely reported. A 34 year-old male, an otherwise healthy patient presented with facial nerve palsy followed by trismus, neck swelling and neck stiffness. Radical mastoidectomy with tympanoplasty and Facial nerve decompression along with Endoscopic guided debridement of sinuses and pterygopalatine fossa followed by medical treatment for 14 weeks. Facial nerve functioning, dry ear canal and relief from other symptoms. Surgical debridement and post op Anti fungal treatment improved the facial nerve function to House brackmann grade-II and also provided relief from trismus and stiffness and improved the overall general condition of the patient. Mucor is a saprophytic organism, which can cause extensive progression, regardless of the immune status. To the best of our knowledge, this is one of the very few rare cases that have been reported in the context of skull base mucormycosis in immunocompetent individuals. Surgical debridement followed by anti fungal therapy continues to remain the mainstay of treatment.

Entities:  

Keywords:  Immunocompetent; Mucormycosis; Otitis media; Pterygopalatine fossa

Year:  2018        PMID: 30906732      PMCID: PMC6401032          DOI: 10.1007/s12070-018-1428-y

Source DB:  PubMed          Journal:  Indian J Otolaryngol Head Neck Surg        ISSN: 2231-3796


  7 in total

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3.  Interferon- gamma and granulocyte-macrophage colony-stimulating factor augment the activity of polymorphonuclear leukocytes against medically important zygomycetes.

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Journal:  J Infect Dis       Date:  2005-02-25       Impact factor: 5.226

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Journal:  Neurosurgery       Date:  2009-10       Impact factor: 4.654

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Journal:  Infection       Date:  1992 Jul-Aug       Impact factor: 3.553

6.  Antifungal activity of colistin against mucorales species in vitro and in a murine model of Rhizopus oryzae pulmonary infection.

Authors:  Ronen Ben-Ami; Russell E Lewis; Jeffrey Tarrand; Konstantinos Leventakos; Dimitrios P Kontoyiannis
Journal:  Antimicrob Agents Chemother       Date:  2009-10-26       Impact factor: 5.191

7.  Imaging of mucormycosis skull base osteomyelitis.

Authors:  L L Chan; S Singh; D Jones; E M Diaz; L E Ginsberg
Journal:  AJNR Am J Neuroradiol       Date:  2000-05       Impact factor: 4.966

  7 in total

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