| Literature DB >> 30906129 |
I Gusti Ngurah Yudhi Setiawan1, I Ketut Suyasa1, Putu Astawa1, I Wayan Suryanto Dusak1, I Ketut Siki Kawiyana1, I Gusti Ngurah Wien Aryana1.
Abstract
Osteoarthritis (OA) arises from imbalance of cartilage metabolism between the synthesis and degradation of type II collagen by the chondrocyte. Collagen type II degradation is characterized by increase in the biomarker of C-telopeptide fragment of type II collagen (CTX-II), while the anabolic process of cartilage is characterized by an increase in the biosynthesis of procollagen amino terminal N-propeptide type IIA (PIIANP). Platelet derived growth factor (PDGF) with Hyaluronic Acid (HA) as a potent growth factor can be used to stimulate the higher formation of chondrocyte and PIIANP levels and lower CTX-II levels in mouse knee osteoarthritis model.Entities:
Keywords: C-telopeptide fragment of type II collagen; Chondrocytes; Knee joint osteoarthritis; Platelet derived growth factor; Procollagen amino terminal N-Propeptide type IIA
Year: 2019 PMID： 30906129 PMCID： PMC6411620 DOI： 10.1016/j.jor.2019.02.028
Source DB: PubMed Journal: J Orthop ISSN： 0972-978X