Yunhui Chen1, Yangpan Ou2, Dan Lv1, Ru Yang3, Sufang Li4, Cuicui Jia1, Yuhua Wang1, Xin Meng5, Hongsheng Cui5, Chengchong Li1, Zhenghai Sun1, Xiaoping Wang2, Wenbin Guo6, Ping Li7. 1. Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China. 2. Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. 3. Department of Radiology, The Second Xiangya Hospital of Central South University. Changsha, Hunan 410011, China. 4. Department of Psychology, Georgetown University, Washington, DC, USA. 5. Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang Province, China. 6. Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.. Electronic address: guowenbin76@csu.edu.cn. 7. Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.. Electronic address: lipingchxyy@163.com.
Abstract
BACKGROUND: Default-mode network (DMN) plays a key role in the pathophysiology of obsessive-compulsive disorder (OCD). However, the network homogeneity (NH) of DMN in OCD remains equivocal. OBJECTIVE: This study aimed to investigate abnormalities in the NH of the DMN at rest and the correlation between the NH of DMN and clinical variables in patients with OCD. METHODS: This study used the independent component analysis and unbiased hypothesis-driven NH method to analyze the resting-state functional magnetic resonance imaging data of 40 drug-naive patients with OCD and 40 age-, gender-, and education-matched healthy controls (HCs). RESULTS: Patients with OCD exhibited decreased NH values in the left ventral medial prefrontal cortex and bilateral posterior cingulate cortex (PCC)/precuneus (PCu) compared with HCs. Furthermore, analyses of receiver operating characteristic curves indicated that the decreased NH values in the right PCC/PCu may be used as a candidate neuroimaging marker to distinguish patients with OCD from HCs. CONCLUSION: These findings contribute new evidence of the participation of the altered NH of the DMN in the pathophysiology of OCD. TRIAL REGISTRATION: Study on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (ChiCTR-COC-17013301).
BACKGROUND: Default-mode network (DMN) plays a key role in the pathophysiology of obsessive-compulsive disorder (OCD). However, the network homogeneity (NH) of DMN in OCD remains equivocal. OBJECTIVE: This study aimed to investigate abnormalities in the NH of the DMN at rest and the correlation between the NH of DMN and clinical variables in patients with OCD. METHODS: This study used the independent component analysis and unbiased hypothesis-driven NH method to analyze the resting-state functional magnetic resonance imaging data of 40 drug-naive patients with OCD and 40 age-, gender-, and education-matched healthy controls (HCs). RESULTS:Patients with OCD exhibited decreased NH values in the left ventral medial prefrontal cortex and bilateral posterior cingulate cortex (PCC)/precuneus (PCu) compared with HCs. Furthermore, analyses of receiver operating characteristic curves indicated that the decreased NH values in the right PCC/PCu may be used as a candidate neuroimaging marker to distinguish patients with OCD from HCs. CONCLUSION: These findings contribute new evidence of the participation of the altered NH of the DMN in the pathophysiology of OCD. TRIAL REGISTRATION: Study on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (ChiCTR-COC-17013301).