Ana Rita Nogueira1,2, Yehuda Shoenfeld1,3, Howard Amital1,3. 1. Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel. 2. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal. 3. Department of Medicine B, Sheba Medical Center, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.