| Literature DB >> 30904819 |
Samuel McLenachan1, Elaine Y M Wong2, Xiao Zhang1, Fiona Leith3, Sang Yoon Moon4, Dan Zhang5, Shang-Chih Chen5, Jennifer A Thompson6, Terri McLaren7, Tina Lamey7, John N De Roach7, Marcus D Atlas8, Rodney J Dilley9, Fred K Chen10.
Abstract
The human iPSC lines LEIi010-A and LEIi010-B were generated from the dermal fibroblasts of a patient with Usher syndrome using episomal plasmids containing OCT4, SOX2, KLF4, L-MYC, LIN28, mir302/367 microRNA and shRNA for p53. These iPSC lines carry compound heterozygous mutations (c.949C > A and c.1256G > T) in USH2A. LEIi010-A and LEIi010-B expressed pluripotent stem cell markers, had a normal karyotype and could be differentiated into endoderm, mesoderm and ectodermal lineages.Entities:
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Year: 2019 PMID： 30904819 DOI： 10.1016/j.scr.2019.101420
Source DB: PubMed Journal: Stem Cell Res ISSN： 1873-5061 Impact factor: 2.020