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Literature DB >> 30904669

Opportunities in precision psychiatry using PET neuroimaging in psychosis.

Jennifer M Coughlin¹, Andrew G Horti², Martin G Pomper³.

Abstract

With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

Entities: Chemical Disease Gene Species

Keywords: Dopamine; Neuroimmunity; PET imaging; Precision medicine; Psychosis; alpha7 nicotinic acetylcholine receptor

Mesh：

Year: 2019 PMID： 30904669 PMCID： PMC6744961 DOI： 10.1016/j.nbd.2019.03.016

Source DB: PubMed Journal: Neurobiol Dis ISSN： 0969-9961 Impact factor: 5.996

76 in total

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