Xin-Yue Zhang1, Dong-Mei Gu2, Jing-Jing Guo3, Qing-Qing Su3, Yan-Bin Chen4. 1. Department of Respiratory Medicine, First People's Hospital of Yuhang District, Hangzhou, China. 2. Department of Pathology and. 3. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China. 4. Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: chen001chen@163.com.
Abstract
BACKGROUND: The objective of this study was to improve the understanding of primary pulmonary lymphoma (PPL) for clinicians. METHODS: We enrolled 27 patients diagnosed with PPL in the First Affiliated Hospital of Soochow University from January 2000 to December 2016. The clinical manifestations, imaging findings, pathologic features, treatments and prognosis of the patients were collected. RESULTS: The male to female ratio was 1.5:1 and the average age was 54.6 ± 15.7 years old. Nine patients were asymptomatic. The main manifestations were cough, expectoration, bloody sputum and fever. The imaging findings presented as nodule, mass, pneumonia or consolidation. There were 2 cases of Hodgkin's lymphoma, 18 cases of non-Hodgkin's lymphoma and 7 cases of undifferentiated lymphoma. Non-Hodgkin's lymphoma cases were divided into T-cell lymphoma (n = 2), mucosa-associated lymphoid tissue lymphoma (MALT) (n = 11), diffuse large B-cell lymphoma (n = 3), small B-cell lymphoma (n = 1) and plasmacytoid B-cell lymphoma (n = 1). Ten MALT cases survived and 1 diffuse large B-cell lymphoma case has been in stable condition for 71 months after surgery and chemotherapy. The international prognostic index was related to the prognosis of PPL. CONCLUSIONS: The clinical manifestations and imaging findings of PPL were nonspecific. The prognosis of MALT was better than other types of PPL. The International prognostic index can be used for predicting the prognosis of PPL.
BACKGROUND: The objective of this study was to improve the understanding of primary pulmonary lymphoma (PPL) for clinicians. METHODS: We enrolled 27 patients diagnosed with PPL in the First Affiliated Hospital of Soochow University from January 2000 to December 2016. The clinical manifestations, imaging findings, pathologic features, treatments and prognosis of the patients were collected. RESULTS: The male to female ratio was 1.5:1 and the average age was 54.6 ± 15.7 years old. Nine patients were asymptomatic. The main manifestations were cough, expectoration, bloody sputum and fever. The imaging findings presented as nodule, mass, pneumonia or consolidation. There were 2 cases of Hodgkin's lymphoma, 18 cases of non-Hodgkin's lymphoma and 7 cases of undifferentiated lymphoma. Non-Hodgkin's lymphoma cases were divided into T-cell lymphoma (n = 2), mucosa-associated lymphoid tissue lymphoma (MALT) (n = 11), diffuse large B-cell lymphoma (n = 3), small B-cell lymphoma (n = 1) and plasmacytoid B-cell lymphoma (n = 1). Ten MALT cases survived and 1 diffuse large B-cell lymphoma case has been in stable condition for 71 months after surgery and chemotherapy. The international prognostic index was related to the prognosis of PPL. CONCLUSIONS: The clinical manifestations and imaging findings of PPL were nonspecific. The prognosis of MALT was better than other types of PPL. The International prognostic index can be used for predicting the prognosis of PPL.
Authors: Damon Kim; Thomas Elgeti; Tobias Penzkofer; Ingo G Steffen; Laura J Jensen; Stefan Schwartz; Bernd Hamm; Sebastian N Nagel Journal: Eur Radiol Date: 2020-08-21 Impact factor: 5.315