Literature DB >> 3090396

Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids.

A M Scofield, L E Fellows, R J Nash, G W Fleet.   

Abstract

Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.

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Year:  1986        PMID： 3090396     DOI： 10.1016/0024-3205(86)90046-9

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  8 in total

1.  Effect of Castanospermine and Related Polyhydroxyalkaloids on Purified Myrosinase from Lepidium sativum Seedlings.

Authors:  P L Durham; J E Poulton
Journal:  Plant Physiol       Date:  1989-05       Impact factor: 8.340

2.  Identification of the genes involved in 1-deoxynojirimycin synthesis in Bacillus subtilis MORI 3K-85.

Authors:  Kyung-Don Kang; Yong Seok Cho; Ji Hye Song; Young Shik Park; Jae Yeon Lee; Kyo Yeol Hwang; Sang Ki Rhee; Ji Hyung Chung; Ohsuk Kwon; Su-Il Seong
Journal:  J Microbiol       Date:  2011-06-30       Impact factor: 3.422

3.  4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.

Authors:  Filipa P da Cruz; Scott Newberry; Sarah F Jenkinson; Mark R Wormald; Terry D Butters; Dominic S Alonzi; Shinpei Nakagawa; Frederic Becq; Caroline Norez; Robert J Nash; Atsushi Kato; George W J Fleet
Journal:  Tetrahedron Lett       Date:  2011-01-12       Impact factor: 2.415

4.  Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

Authors:  A Karpas; G W Fleet; R A Dwek; S Petursson; S K Namgoong; N G Ramsden; G S Jacob; T W Rademacher
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

5.  Differential inhibition by castanospermine of various insect disaccharidases.

Authors:  B C Campbell; R J Molyneux; K C Jones
Journal:  J Chem Ecol       Date:  1987-07       Impact factor: 2.626

Review 6.  Pharmacological Chaperone Therapy for Pompe Disease.

Authors:  Marc Borie-Guichot; My Lan Tran; Yves Génisson; Stéphanie Ballereau; Cécile Dehoux
Journal:  Molecules       Date:  2021-11-29       Impact factor: 4.411

7.  Loss of cytomegalovirus infectivity after treatment with castanospermine or related plant alkaloids correlates with aberrant glycoprotein synthesis.

Authors:  D L Taylor; L E Fellows; G H Farrar; R J Nash; D Taylor-Robinson; M A Mobberley; T A Ryder; D J Jeffries; A S Tyms
Journal:  Antiviral Res       Date:  1988-11       Impact factor: 5.970

Review 8.  Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis.

Authors:  Anna Esposito; Daniele D'Alonzo; Maria De Fenza; Eliana De Gregorio; Anna Tamanini; Giuseppe Lippi; Maria Cristina Dechecchi; Annalisa Guaragna
Journal:  Int J Mol Sci       Date:  2020-05-09       Impact factor: 5.923
  8 in total

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