Louren M Goedhart1, Vincent K Y Ho2, P D S Dijkstra3, Hendrik W B Schreuder4, Gerard R Schaap5, Joris J W Ploegmakers6, Ingrid C M van der Geest4, Michiel A J van de Sande3, Jos A Bramer5, Albert J H Suurmeijer7, Paul C Jutte6. 1. Department of Orthopaedic Surgery, University Medical Center Groningen, the Netherlands. Electronic address: l.m.goedhart@umcg.nl. 2. Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands. 3. Department of Orthopaedic Surgery, Leiden University Medical Center, the Netherlands. 4. Department of Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, the Netherlands. 5. Department of Orthopaedic Surgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands. 6. Department of Orthopaedic Surgery, University Medical Center Groningen, the Netherlands. 7. Department of Pathology, University Medical Center Groningen, the Netherlands.
Abstract
AIMS: Chondrosarcoma, osteosarcoma and Ewing sarcoma form the majority of malignant primary tumours of bone. High-grade bone sarcomas require intensive treatment due to their rapid and invasive growth pattern and metastasising capabilities. This nationwide study covers overall incidence, treatment and survival patterns of bone sarcomas in a 15-year period (2000-2014) in the total population of the Netherlands. PATIENTS AND METHODS: Data for this study were derived from the Netherlands Cancer Registry, which receives primary notification from the national pathology database. Classification and categorisation was based on the ICD-O-3 classification and the WHO classification 2013 applied according to our clinicopathological expertise. Overall incidence over the 15-year-period was calculated as a rate per 100,000 person-years (using the European Standardised Rate, ESR). Survival was analysed with Kaplan-Meier curves and Cox proportional hazards regression. RESULTS: Incidence for high-grade chondrosarcoma (n = 429) was estimated at 0.15 per 100,000 ESR, and 5-year overall survival at 65.9% (95% confidence interval (CI): 61.0%-70.4%). Incidence for high-grade central osteosarcoma (n = 605) was estimated at 0.25 per 100,000 ESR and 5-year survival at 53.9% (95%CI: 49.7%-58.0%). Ewing sarcoma incidence (n = 334) was estimated at 0.15 per 100,000 ESR and 5-year survival at 59.3% (95%CI: 53.5%-64.6%). For high-grade central osteosarcoma, treatment at a bone tumour centre was associated with better survival (HR 0.593). CONCLUSIONS: This study provides comprehensive incidence estimates for all the main primary bone sarcomas over a 15-year time period in a Northern European country with little migration. Centralisation of bone sarcoma care improves the clinical outcome in osteosarcoma.
AIMS: Chondrosarcoma, osteosarcoma and Ewing sarcoma form the majority of malignant primary tumours of bone. High-grade bone sarcomas require intensive treatment due to their rapid and invasive growth pattern and metastasising capabilities. This nationwide study covers overall incidence, treatment and survival patterns of bone sarcomas in a 15-year period (2000-2014) in the total population of the Netherlands. PATIENTS AND METHODS: Data for this study were derived from the Netherlands Cancer Registry, which receives primary notification from the national pathology database. Classification and categorisation was based on the ICD-O-3 classification and the WHO classification 2013 applied according to our clinicopathological expertise. Overall incidence over the 15-year-period was calculated as a rate per 100,000 person-years (using the European Standardised Rate, ESR). Survival was analysed with Kaplan-Meier curves and Cox proportional hazards regression. RESULTS: Incidence for high-grade chondrosarcoma (n = 429) was estimated at 0.15 per 100,000 ESR, and 5-year overall survival at 65.9% (95% confidence interval (CI): 61.0%-70.4%). Incidence for high-grade central osteosarcoma (n = 605) was estimated at 0.25 per 100,000 ESR and 5-year survival at 53.9% (95%CI: 49.7%-58.0%). Ewing sarcoma incidence (n = 334) was estimated at 0.15 per 100,000 ESR and 5-year survival at 59.3% (95%CI: 53.5%-64.6%). For high-grade central osteosarcoma, treatment at a bone tumour centre was associated with better survival (HR 0.593). CONCLUSIONS: This study provides comprehensive incidence estimates for all the main primary bone sarcomas over a 15-year time period in a Northern European country with little migration. Centralisation of bone sarcoma care improves the clinical outcome in osteosarcoma.
Authors: Eline de Heus; Vivian Engelen; Irene Dingemans; Carol Richel; Marga Schrieks; Jan Maarten van der Zwan; Marc G Besselink; Mark I van Berge Henegouwen; Carla M L van Herpen; Saskia F A Duijts Journal: Orphanet J Rare Dis Date: 2021-06-01 Impact factor: 4.123