Feng Gao1, Ming Li2,3,4, Ziwei Zhang5, Li Xiao6, Guozhen Zhang1, Xiangpeng Zheng7, Yanqing Hua1, Jianying Li8. 1. Department of Radiology, Huadong Hospital Fudan University, Shanghai, 200040, China. 2. Department of Radiology, Huadong Hospital Fudan University, Shanghai, 200040, China. minli77@163.com. 3. Diagnostic and Treatment Center of Small Lung Nodules, Huadong Hospital Fudan University, 221#, West Yanan Road, Shanghai, 200040, China. minli77@163.com. 4. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, 200040, China. minli77@163.com. 5. Department of Radiology, Duke University Medical Center, Durham, NC, USA. 6. Department of Pathology, Huadong Hospital Fudan University, Shanghai, 200040, China. 7. Diagnostic and Treatment Center of Small Lung Nodules, Huadong Hospital Fudan University, 221#, West Yanan Road, Shanghai, 200040, China. 8. CT Research Center, GE Healthcare China, Shanghai, 200040, China.
Abstract
OBJECTIVE: To retrospectively analyze the computed tomography (CT) features in patients with pre-invasive lesions and early-stage lung adenocarcinoma and to explore the correlation between tumor morphological changes and pathological diagnoses. MATERIALS AND METHODS: CT morphological characteristics in 2106 patients with pre-invasive (stage 0) and early-stage (stage I) lung adenocarcinoma were analyzed; lesions were confirmed by surgical pathology. Based on the morphological characteristics, the lesions were divided into eight types: I (cotton ball, ground-glass nodules), II (solid fill), III (granular), IV (dendriform), V (bubble-like lucencies), VI (alveolate or honeycomb), VII (scar-like), and VIII (notched or umbilication). The different distributions of eight morphological types in pathological types of the lesions and subtypes of invasive adenocarcinoma were analyzed by chi-squared or Fisher's exact test. Correlation between the percentage of ground-glass opacity in the lesions and pathology types were analyzed by two-tailed Pearson's test. RESULTS: A negative correlation was observed between the pathological types and proportion of ground-glass component in the lesions (p < 0.001 and r = - 0.583). Significant differences in morphological characteristics among various pathological types of pre-invasive lesions and early lung adenocarcinomas were observed (p < 0.05). Furthermore, among the different pathological subtypes of stage I invasive adenocarcinoma, the differences in their manifestation as morphological types I, II, III, and VI were statistically significant (p < 0.05). CONCLUSION: The eight types of morphological classification of pre-invasive lesions and early-stage (stage 0 or stage I) lung adenocarcinoma has different pathological bases, and morphological classification may be useful for the diagnosis and differential diagnosis of lung adenocarcinoma. KEY POINTS: • CT morphological classification of pre-invasive lesions and lung adenocarcinoma is intuitive. • CT morphological classification characterizes morphological changes of the entire lesion. • Different pathological types of lung adenocarcinoma have different morphological features.
OBJECTIVE: To retrospectively analyze the computed tomography (CT) features in patients with pre-invasive lesions and early-stage lung adenocarcinoma and to explore the correlation between tumor morphological changes and pathological diagnoses. MATERIALS AND METHODS: CT morphological characteristics in 2106 patients with pre-invasive (stage 0) and early-stage (stage I) lung adenocarcinoma were analyzed; lesions were confirmed by surgical pathology. Based on the morphological characteristics, the lesions were divided into eight types: I (cotton ball, ground-glass nodules), II (solid fill), III (granular), IV (dendriform), V (bubble-like lucencies), VI (alveolate or honeycomb), VII (scar-like), and VIII (notched or umbilication). The different distributions of eight morphological types in pathological types of the lesions and subtypes of invasive adenocarcinoma were analyzed by chi-squared or Fisher's exact test. Correlation between the percentage of ground-glass opacity in the lesions and pathology types were analyzed by two-tailed Pearson's test. RESULTS: A negative correlation was observed between the pathological types and proportion of ground-glass component in the lesions (p < 0.001 and r = - 0.583). Significant differences in morphological characteristics among various pathological types of pre-invasive lesions and early lung adenocarcinomas were observed (p < 0.05). Furthermore, among the different pathological subtypes of stage I invasive adenocarcinoma, the differences in their manifestation as morphological types I, II, III, and VI were statistically significant (p < 0.05). CONCLUSION: The eight types of morphological classification of pre-invasive lesions and early-stage (stage 0 or stage I) lung adenocarcinoma has different pathological bases, and morphological classification may be useful for the diagnosis and differential diagnosis of lung adenocarcinoma. KEY POINTS: • CT morphological classification of pre-invasive lesions and lung adenocarcinoma is intuitive. • CT morphological classification characterizes morphological changes of the entire lesion. • Different pathological types of lung adenocarcinoma have different morphological features.
Authors: T Aoki; Y Tomoda; H Watanabe; H Nakata; T Kasai; H Hashimoto; M Kodate; T Osaki; K Yasumoto Journal: Radiology Date: 2001-09 Impact factor: 11.105
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