Andrea Kapinova1, Peter Kubatka2,3, Alena Liskova4, Denis Baranenko5, Peter Kruzliak6,7,8, Milan Matta9, Dietrich Büsselberg10, Bibiana Malicherova1, Anthony Zulli11, Taeg Kyu Kwon12, Eva Jezkova13, Dana Blahutova14, Pavol Zubor1,4, Jan Danko4. 1. Biomedical Center Martin, Division of Oncology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. 2. Biomedical Center Martin, Division of Oncology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. kubatka@jfmed.uniba.sk. 3. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 036 01, Martin, Slovakia. kubatka@jfmed.uniba.sk. 4. Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine and Martin University Hospital, Comenius University in Bratislava, Martin, Slovakia. 5. International Research Centre "Biotechnologies of the Third Millennium", ITMO University, Saint-Petersburg, Russian Federation. 6. Department of Internal Medicine, Brothers of Mercy Hospital, Polní 3, 639 00, Brno, Czech Republic. kruzliakpeter@gmail.com. 7. 2nd Department of Surgery, Faculty of Medicine, Masaryk University, Brno, Czech Republic. kruzliakpeter@gmail.com. 8. St. Anne's University Hospital, Brno, Czech Republic. kruzliakpeter@gmail.com. 9. Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef Safarik University and University Hospital, Kosice, Slovakia. 10. Department of Physiology and Biophysics, Weill Cornell College of Medicine, Education City, Qatar Foundation, Doha, Qatar. 11. Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia. 12. Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea. 13. Department of Histology and Embryology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. 14. Department of Biology and Ecology, Faculty of Education, Catholic University in Ruzomberok, Ruzomberok, Slovakia.
Abstract
PURPOSE: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. RESULTS: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. CONCLUSIONS: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
PURPOSE:Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancerpatients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. RESULTS: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. CONCLUSIONS: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
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Authors: Olga Golubnitschaja; Peter Kubatka; Alena Mazurakova; Marek Samec; Abdullah Alajati; Frank A Giordano; Vincenzo Costigliola; Jörg Ellinger; Manuel Ritter Journal: Cancers (Basel) Date: 2022-01-28 Impact factor: 6.639
Authors: Alena Mazurakova; Marek Samec; Lenka Koklesova; Kamil Biringer; Erik Kudela; Raghad Khalid Al-Ishaq; Martin Pec; Frank A Giordano; Dietrich Büsselberg; Peter Kubatka; Olga Golubnitschaja Journal: EPMA J Date: 2022-07-08 Impact factor: 8.836
Authors: Lenka Koklesova; Alena Liskova; Marek Samec; Tawar Qaradakhi; Anthony Zulli; Karel Smejkal; Karol Kajo; Jana Jakubikova; Payam Behzadi; Martin Pec; Pavol Zubor; Kamil Biringer; Taeg Kyu Kwon; Dietrich Büsselberg; Gustavo R Sarria; Frank A Giordano; Olga Golubnitschaja; Peter Kubatka Journal: EPMA J Date: 2020-05-29 Impact factor: 6.543