Tiago M Rodrigues1,2,3, João P Marques4,5,6, Mário Soares4, Sílvia Simão5, Pedro Melo4, Amélia Martins4, João Figueira4,5,6, Joaquim N Murta4,5,6, Rufino Silva4,5,6. 1. Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra - CHUC, E.P.E. Praceta Professor Mota Pinto, 3000-075, Coimbra, Portugal. tiago.fm.rod@gmail.com. 2. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal. tiago.fm.rod@gmail.com. 3. Institute of Molecular and Clinical Ophthalmology Basel (IOB), Mittlere Strasse 91, CH-4031, Basel, Switzerland. tiago.fm.rod@gmail.com. 4. Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra - CHUC, E.P.E. Praceta Professor Mota Pinto, 3000-075, Coimbra, Portugal. 5. Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal. 6. Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, 3004-204, Coimbra, Portugal.
Abstract
BACKGROUND: To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. METHODS: Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with nonproliferative DR (up to ETDRS Level 53) were evaluated with OCTA (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Seven-field photographs of the fundus were taken for DR staging according to the ETDRS-grading scheme. The vessel density in the superficial and deep capillary plexus (SCP and DCP, respectively), as well as in the choriocapillaris (CC), were calculated using automated software. Univariate and multivariate ordered logistic regression models were used in the analysis. P < 0.05 was considered statistically significant. RESULTS: We included 101 eyes from 56 subjects (mean (SD) age 62.64 (11.74) years; 57.4% were male). On univariate analysis, several OCTA parameters were found to be associated with higher ETDRS level (parafoveal SCP density: OR = 0.87 (95% CI 0.76-0.99), p = 0.039; parafoveal DCP density: OR = 0.79 (95% CI 0.72-0.87), p < 0.001; CC density: OR = 0.89 (95% CI 0.80-0.99)), p = 0.036). In the final model, while also adjusting for relevant clinical features, only parafoveal vessel density in the DCP remained as a significant predictor of NPDR ETDRS level (OR = 0.54 (95% CI 0.32-0.92), p = 0.024). CONCLUSION: Our results suggest that parafoveal vessel density in the DCP is the parameter most robustly associated with ETDRS level. OCTA analysis may provide objective imaging biomarkers to monitor NPDR clinical progression.
BACKGROUND: To test whether a single or a composite set of macular vascular density parameters, evaluated with optical coherence tomography angiography (OCTA), are able to predict nonproliferative diabetic retinopathy (NPDR) staging according to the gold-standard ETDRS-grading scheme. METHODS: Prospectively defined, cross-sectional study in which macular structural and vascular parameters of diabetic eyes with nonproliferative DR (up to ETDRS Level 53) were evaluated with OCTA (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Seven-field photographs of the fundus were taken for DR staging according to the ETDRS-grading scheme. The vessel density in the superficial and deep capillary plexus (SCP and DCP, respectively), as well as in the choriocapillaris (CC), were calculated using automated software. Univariate and multivariate ordered logistic regression models were used in the analysis. P < 0.05 was considered statistically significant. RESULTS: We included 101 eyes from 56 subjects (mean (SD) age 62.64 (11.74) years; 57.4% were male). On univariate analysis, several OCTA parameters were found to be associated with higher ETDRS level (parafoveal SCP density: OR = 0.87 (95% CI 0.76-0.99), p = 0.039; parafoveal DCP density: OR = 0.79 (95% CI 0.72-0.87), p < 0.001; CC density: OR = 0.89 (95% CI 0.80-0.99)), p = 0.036). In the final model, while also adjusting for relevant clinical features, only parafoveal vessel density in the DCP remained as a significant predictor of NPDR ETDRS level (OR = 0.54 (95% CI 0.32-0.92), p = 0.024). CONCLUSION: Our results suggest that parafoveal vessel density in the DCP is the parameter most robustly associated with ETDRS level. OCTA analysis may provide objective imaging biomarkers to monitor NPDR clinical progression.
Authors: Silvia M Sanz-González; José J García-Medina; Vicente Zanón-Moreno; María I López-Gálvez; David Galarreta-Mira; Lilianne Duarte; Mar Valero-Velló; Ana I Ramírez; J Fernando Arévalo; María D Pinazo-Durán Journal: Antioxidants (Basel) Date: 2020-11-09
Authors: Nina C B B Veiby; Aida Simeunovic; Martin Heier; Cathrine Brunborg; Naila Saddique; Morten C Moe; Knut Dahl-Jørgensen; Hanna D Margeirsdottir; Goran Petrovski Journal: J Diabetes Res Date: 2020-11-30 Impact factor: 4.011