Dorothy D Dunlop1, Jing Song2, Jennifer M Hootman3, Michael C Nevitt4, Pamela A Semanik5, Jungwha Lee6, Leena Sharma7, Charles B Eaton8, Marc C Hochberg9, Rebecca D Jackson10, C Kent Kwoh11, Rowland W Chang12. 1. Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Electronic address: ddunlop@northwestern.edu. 2. Institute of Public Health and Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. 3. Arthritis Program, Division of Population Health, Centers for Disease Control and Prevention, Atlanta, Georgia. 4. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California. 5. Department of Adult Health and Gerontological Nursing, Rush University, College of Nursing, Chicago, Illinois. 6. Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. 7. Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. 8. Department of Family Medicine, Brown University, Alpert Medical School, Pawtucket, Rhode Island; Department of Epidemiology, Brown University, Alpert Medical School, Pawtucket, Rhode Island. 9. Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland; Department of Epidemiology and Public Health, University of Maryland, School of Medicine, Baltimore, Maryland. 10. Department of Internal Medicine, The Ohio State University, Columbus, Ohio. 11. Department of Medicine, University of Arizona, College of Medicine, Tucson, Arizona; Department of Medical Imaging, University of Arizona, College of Medicine, Tucson, Arizona. 12. Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Physical Medicine and Rehabilitation, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Abstract
INTRODUCTION: Physical activity guidelines recommend minimum thresholds. This study sought to identify evidence-based thresholds to maintain disability-free status over 4years among adults with lower extremity joint symptoms. METHODS: Prospective multisite Osteoarthritis Initiative accelerometer monitoring cohort data from September 2008 through December 2014 were analyzed. Adults (n=1,564) aged ≥49years at elevated disability risk because of lower extremity joint symptoms were analyzed for biennial assessments of disability-free status from gait speed ≥1meter/second (mobility disability-free) and self-report of no limitations in activities of daily living (activities of daily living disability-free). Classification tree analyses conducted in 2017-2018 identified optimal thresholds across candidate activity intensities (sedentary, light, moderate-vigorous, total light and moderate-vigorous activity, and moderate-vigorous accrued in bouts lasting ≥10 minutes). RESULTS: Minimal thresholds of 56 and 55 moderate-vigorous minutes/week best predicted disability-free status over 4years from mobility and activities of daily living disabilities, respectively, across the candidate measures. Thresholds were consistent across sex, BMI, age, and knee osteoarthritis presence. Mobility disability onset was one eighth as frequent (3% vs 24%, RR=0.14, 95% CI=0.09, 0.20) and activities of daily living disability onset was almost half (12% vs 23%, RR=0.55, 95% CI=0.44, 0.70) among people above versus below the minimum threshold. CONCLUSIONS: Attaining an evidence-based threshold of approximately 1-hour moderate-vigorous activity/week significantly increased the likelihood of maintaining disability-free status over 4years. This minimum threshold tied to maintaining independent living abilities has value as an intermediate goal to motivate adults to take action towards the many health benefits of a physically active lifestyle.
INTRODUCTION: Physical activity guidelines recommend minimum thresholds. This study sought to identify evidence-based thresholds to maintain disability-free status over 4years among adults with lower extremity joint symptoms. METHODS: Prospective multisite Osteoarthritis Initiative accelerometer monitoring cohort data from September 2008 through December 2014 were analyzed. Adults (n=1,564) aged ≥49years at elevated disability risk because of lower extremity joint symptoms were analyzed for biennial assessments of disability-free status from gait speed ≥1meter/second (mobility disability-free) and self-report of no limitations in activities of daily living (activities of daily living disability-free). Classification tree analyses conducted in 2017-2018 identified optimal thresholds across candidate activity intensities (sedentary, light, moderate-vigorous, total light and moderate-vigorous activity, and moderate-vigorous accrued in bouts lasting ≥10 minutes). RESULTS: Minimal thresholds of 56 and 55 moderate-vigorous minutes/week best predicted disability-free status over 4years from mobility and activities of daily living disabilities, respectively, across the candidate measures. Thresholds were consistent across sex, BMI, age, and knee osteoarthritis presence. Mobility disability onset was one eighth as frequent (3% vs 24%, RR=0.14, 95% CI=0.09, 0.20) and activities of daily living disability onset was almost half (12% vs 23%, RR=0.55, 95% CI=0.44, 0.70) among people above versus below the minimum threshold. CONCLUSIONS: Attaining an evidence-based threshold of approximately 1-hour moderate-vigorous activity/week significantly increased the likelihood of maintaining disability-free status over 4years. This minimum threshold tied to maintaining independent living abilities has value as an intermediate goal to motivate adults to take action towards the many health benefits of a physically active lifestyle.
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