Literature DB >> 30901610

AKTivation mechanisms.

Philip A Cole1, Nam Chu2, Antonieta L Salguero3, Hwan Bae2.   

Abstract

Akt1-3 (Akt) are a subset of the AGC protein Ser/Thr kinase family and play important roles in cell growth, metabolic regulation, cancer, and other diseases. We describe some of the roles of Akt in cell signaling and the biochemical and structural mechanisms of the regulation of Akt catalysis by the phospholipid PIP3 and by phosphorylation. Recent findings highlight a diverse set of strategies to control Akt catalytic activity to ensure its normal biological functions.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2019        PMID： 30901610      PMCID： PMC6752985          DOI： 10.1016/j.sbi.2019.02.004

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  51 in total

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Journal:  Science       Date:  2001-08-10       Impact factor: 47.728

2.  Identifying protein kinase target preferences using mass spectrometry.

Authors:  Jacqueline Douglass; Ruwan Gunaratne; Davis Bradford; Fahad Saeed; Jason D Hoffert; Peter J Steinbach; Mark A Knepper; Trairak Pisitkun
Journal:  Am J Physiol Cell Physiol       Date:  2012-06-20       Impact factor: 4.249

3.  Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Authors:  Emilie Vander Haar; Seong-Il Lee; Sricharan Bandhakavi; Timothy J Griffin; Do-Hyung Kim
Journal:  Nat Cell Biol       Date:  2007-02-04       Impact factor: 28.824

4.  Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.

Authors:  Revati Wani; Jiang Qian; Leimiao Yin; Erika Bechtold; S Bruce King; Leslie B Poole; Eunok Paek; Allen W Tsang; Cristina M Furdui
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

Review 5.  The nuts and bolts of AGC protein kinases.

Authors:  Laura R Pearce; David Komander; Dario R Alessi
Journal:  Nat Rev Mol Cell Biol       Date:  2010-01       Impact factor: 94.444

Review 6.  Kinase inhibitors: the road ahead.

Authors:  Fleur M Ferguson; Nathanael S Gray
Journal:  Nat Rev Drug Discov       Date:  2018-03-16       Impact factor: 84.694

7.  Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

Authors:  S P Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

8.  Mechanism-based design of a protein kinase inhibitor.

Authors:  K Parang; J H Till; A J Ablooglu; R A Kohanski; S R Hubbard; P A Cole
Journal:  Nat Struct Biol       Date:  2001-01

9.  Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.

Authors:  S Paradis; G Ruvkun
Journal:  Genes Dev       Date:  1998-08-15       Impact factor: 11.361

10.  Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.

Authors:  B M Burgering; P J Coffer
Journal:  Nature       Date:  1995-08-17       Impact factor: 49.962
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  11 in total

1.  mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Authors:  Timothy R Baffi; Gema Lordén; Jacob M Wozniak; Andreas Feichtner; Wayland Yeung; Alexandr P Kornev; Charles C King; Jason C Del Rio; Ameya J Limaye; Julius Bogomolovas; Christine M Gould; Ju Chen; Eileen J Kennedy; Natarajan Kannan; David J Gonzalez; Eduard Stefan; Susan S Taylor; Alexandra C Newton
Journal:  Sci Signal       Date:  2021-04-13       Impact factor: 8.192

2.  Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.

Authors:  Antonieta L Salguero; Maggie Chen; Aaron T Balana; Nam Chu; Hanjie Jiang; Brad A Palanski; Hwan Bae; Katharine M Wright; Sara Nathan; Heng Zhu; Sandra B Gabelli; Matthew R Pratt; Philip A Cole
Journal:  ACS Chem Biol       Date:  2021-12-23       Impact factor: 5.100

3.  Post-translational modifications and stress adaptation: the paradigm of FKBP51.

Authors:  Theo Rein
Journal:  Biochem Soc Trans       Date:  2020-04-29       Impact factor: 5.407

4.  Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer.

Authors:  Renata A M Rossetti; Ildefonso A da Silva-Junior; Gretel R Rodríguez; Karla L F Alvarez; Simone C Stone; Marcella Cipelli; Caio R F Silveira; Mariana Carmezim Beldi; Giana R Mota; Paulo F R Margarido; Edmund C Baracat; Miyuki Uno; Luisa L Villa; Jesus P Carvalho; Kaori Yokochi; Maria Beatriz S F Rosa; Noely P Lorenzi; Ana Paula Lepique
Journal:  Front Oncol       Date:  2020-11-19       Impact factor: 6.244

Review 5.  Primary cilia and lipid raft dynamics.

Authors:  Yuhei Nishimura; Daishi Yamakawa; Katsunori Uchida; Takashi Shiromizu; Masatoshi Watanabe; Masaki Inagaki
Journal:  Open Biol       Date:  2021-08-25       Impact factor: 6.411

6.  A Highly Sensitive Fluorescent Akt Biosensor Reveals Lysosome-Selective Regulation of Lipid Second Messengers and Kinase Activity.

Authors:  Mingyuan Chen; Tengqian Sun; Yanghao Zhong; Xin Zhou; Jin Zhang
Journal:  ACS Cent Sci       Date:  2021-12-03       Impact factor: 14.553

7.  Network Pharmacology-Based Identification of Potential Targets of Lonicerae japonicae Flos Acting on Anti-Inflammatory Effects.

Authors:  Xiaoying Guo; Xiao Yu; Bingqing Zheng; Longfei Zhang; Fang Zhang; Yongqing Zhang; Jia Li; Gaobin Pu; Lijun Zhang; Haifeng Wu
Journal:  Biomed Res Int       Date:  2021-09-20       Impact factor: 3.411

8.  Exploring the mechanism of Buyang Huanwu decoction in the treatment of lumbar disc herniation based on network pharmacology and molecular docking.

Authors:  Yong Gu; Haijia Zhu; Xiaojian Wang; Shanxing Zhang; Peijian Tong; Shuaijie Lv
Journal:  Medicine (Baltimore)       Date:  2022-08-12       Impact factor: 1.817

9.  The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling.

Authors:  Nam Chu; Thibault Viennet; Hwan Bae; Antonieta Salguero; Andras Boeszoermenyi; Haribabu Arthanari; Philip A Cole
Journal:  Elife       Date:  2020-08-03       Impact factor: 8.140

10.  Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations.

Authors:  Dominika Rittler; Eszter Molnár; Marcell Baranyi; Tamás Garay; Luca Hegedűs; Clemens Aigner; József Tóvári; József Tímár; Balázs Hegedűs
Journal:  Int J Mol Sci       Date:  2020-10-16       Impact factor: 5.923
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