Literature DB >> 30901541

The Genetics of Aging: A Vertebrate Perspective.

Param Priya Singh1, Brittany A Demmitt1, Ravi D Nath1, Anne Brunet2.   

Abstract

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is more complex in vertebrates because of their specialized systems. This Review discusses advances in the genetic regulation of aging in vertebrates from work in mice, humans, and organisms with exceptional lifespans. We highlight challenges for the future, including sex-dependent differences in lifespan and the interplay between genes and environment. We also discuss how the identification of reliable biomarkers of age and development of new vertebrate models can be leveraged for personalized interventions to counter aging and age-related diseases.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Year:  2019        PMID： 30901541      PMCID： PMC7592626          DOI： 10.1016/j.cell.2019.02.038

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  182 in total

Review 1.  The genetics of ageing.

Authors:  Cynthia J Kenyon
Journal:  Nature       Date:  2010-03-25       Impact factor: 49.962

2.  Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.

Authors:  Paola Sebastiani; Anastasia Gurinovich; Harold Bae; Stacy Andersen; Alberto Malovini; Gil Atzmon; Francesco Villa; Aldi T Kraja; Danny Ben-Avraham; Nir Barzilai; Annibale Puca; Thomas T Perls
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-10-12       Impact factor: 6.053

3.  Aging as a Biological Target for Prevention and Therapy.

Authors:  Nir Barzilai; Ana Maria Cuervo; Steve Austad
Journal:  JAMA       Date:  2018-10-02       Impact factor: 56.272

4.  The sirtuin SIRT6 regulates lifespan in male mice.

Authors:  Yariv Kanfi; Shoshana Naiman; Gail Amir; Victoria Peshti; Guy Zinman; Liat Nahum; Ziv Bar-Joseph; Haim Y Cohen
Journal:  Nature       Date:  2012-02-22       Impact factor: 49.962

5.  Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A.

Authors:  Cheryl A Conover; Laurie K Bale; Jessica R Mader; Megan A Mason; Kevin P Keenan; Ronald J Marler
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-03-29       Impact factor: 6.053

6.  Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.

Authors:  Viviana I Pérez; Rochelle Buffenstein; Venkata Masamsetti; Shanique Leonard; Adam B Salmon; James Mele; Blazej Andziak; Ting Yang; Yael Edrey; Bertrand Friguet; Walter Ward; Arlan Richardson; Asish Chaudhuri
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-17       Impact factor: 11.205

7.  Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Authors:  Sarah J Mitchell; Julio Madrigal-Matute; Morten Scheibye-Knudsen; Evandro Fang; Miguel Aon; José A González-Reyes; Sonia Cortassa; Susmita Kaushik; Marta Gonzalez-Freire; Bindi Patel; Devin Wahl; Ahmed Ali; Miguel Calvo-Rubio; María I Burón; Vincent Guiterrez; Theresa M Ward; Hector H Palacios; Huan Cai; David W Frederick; Christopher Hine; Filomena Broeskamp; Lukas Habering; John Dawson; T Mark Beasley; Junxiang Wan; Yuji Ikeno; Gene Hubbard; Kevin G Becker; Yongqing Zhang; Vilhelm A Bohr; Dan L Longo; Placido Navas; Luigi Ferrucci; David A Sinclair; Pinchas Cohen; Josephine M Egan; James R Mitchell; Joseph A Baur; David B Allison; R Michael Anson; José M Villalba; Frank Madeo; Ana Maria Cuervo; Kevin J Pearson; Donald K Ingram; Michel Bernier; Rafael de Cabo
Journal:  Cell Metab       Date:  2016-06-14       Impact factor: 27.287

8.  Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age.

Authors:  J Graham Ruby; Megan Smith; Rochelle Buffenstein
Journal:  Elife       Date:  2018-01-24       Impact factor: 8.140

9.  Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking.

Authors:  Jamshid Faraji; Mitra Karimi; Nabiollah Soltanpour; Alireza Moharrerie; Zahra Rouhzadeh; Hamid Lotfi; S Abedin Hosseini; S Yaghoob Jafari; Shabnam Roudaki; Reza Moeeini; Gerlinde As Metz
Journal:  Elife       Date:  2018-11-13       Impact factor: 8.140

10.  Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms.

Authors:  Adrian J Lambert; Helen M Boysen; Julie A Buckingham; Ting Yang; Andrej Podlutsky; Steven N Austad; Thomas H Kunz; Rochelle Buffenstein; Martin D Brand
Journal:  Aging Cell       Date:  2007-06-27       Impact factor: 9.304
View more
  60 in total

1.  Asynchronous, contagious and digital aging.

Authors:  Thomas A Rando; Tony Wyss-Coray
Journal:  Nat Aging       Date:  2021-01-14

Review 2.  Genetic Support for Longevity-Enhancing Drug Targets: Issues, Preliminary Data, and Future Directions.

Authors:  Jamison McCorrison; Thomas Girke; Laura H Goetz; Richard A Miller; Nicholas J Schork
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2019-11-13       Impact factor: 6.053

3.  Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.

Authors:  Svetlana Ukraintseva; Konstantin Arbeev; Matt Duan; Igor Akushevich; Alexander Kulminski; Eric Stallard; Anatoliy Yashin
Journal:  Mech Ageing Dev       Date:  2020-12-16       Impact factor: 5.432

Review 4.  Mitonuclear genomics and aging.

Authors:  Joseph C Reynolds; Conscience P Bwiza; Changhan Lee
Journal:  Hum Genet       Date:  2020-01-29       Impact factor: 4.132

Review 5.  Proteomics of Long-Lived Mammals.

Authors:  Gregory Tombline; Jonathan Gigas; Nicholas Macoretta; Max Zacher; Stephan Emmrich; Yang Zhao; Andrei Seluanov; Vera Gorbunova
Journal:  Proteomics       Date:  2020-01-09       Impact factor: 3.984

Review 6.  Measuring biological age using omics data.

Authors:  Jarod Rutledge; Hamilton Oh; Tony Wyss-Coray
Journal:  Nat Rev Genet       Date:  2022-06-17       Impact factor: 53.242

Review 7.  Rhesus macaques as a tractable physiological model of human ageing.

Authors:  Kenneth L Chiou; Michael J Montague; Elisabeth A Goldman; Marina M Watowich; Sierra N Sams; Jeff Song; Julie E Horvath; Kirstin N Sterner; Angelina V Ruiz-Lambides; Melween I Martínez; James P Higham; Lauren J N Brent; Michael L Platt; Noah Snyder-Mackler
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-09-21       Impact factor: 6.237

Review 8.  Loss of chromatin structural integrity is a source of stress during aging.

Authors:  Ruofan Yu; Brenna McCauley; Weiwei Dang
Journal:  Hum Genet       Date:  2020-01-03       Impact factor: 4.132

Review 9.  Importance of circadian timing for aging and longevity.

Authors:  Victoria A Acosta-Rodríguez; Filipa Rijo-Ferreira; Carla B Green; Joseph S Takahashi
Journal:  Nat Commun       Date:  2021-05-17       Impact factor: 14.919

Review 10.  Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.

Authors:  Shuling Song; Eric W-F Lam; Tamara Tchkonia; James L Kirkland; Yu Sun
Journal:  Trends Biochem Sci       Date:  2020-04-06       Impact factor: 13.807
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.