| Literature DB >> 30901225 |
Tao Zhang1,2, Hong-Cheng Shen1,2, Jia-Cheng Xu1, Tao Fan1, Zhi-Yong Han1, Liu-Zhu Gong1,2.
Abstract
The first Pd(II)-catalyzed asymmetric oxidative annulation of N-alkoxyaryl amides and 1,3-dienes is reported, which features particular applicability for quick assembly of different types of chiral heterocycles with high yields and enantioselectivities. A novel chiral pyridine-oxazoline bearing a methoxyl group at the C-5 position and a gem-dimethyl group on the oxazoline moiety was found to be crucial for conversion.Entities:
Year: 2019 PMID： 30901225 DOI： 10.1021/acs.orglett.9b00216
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005