Sukhpreet Klaire1, Rebecca Zivanovic2,3, Skye Pamela Barbic2,4,5, Raman Sandhu3, Nickie Mathew3,6, Pouya Azar2,3,7. 1. British Columbia Centre on Substance Use, Vancouver, Canadian Province, Canada. 2. Foundry Central Office, Vancouver, Canadian Province, Canada. 3. University of British Columbia, Vancouver, Canadian Province, Canada. 4. Department of Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, Canadian Province, Canada. 5. Centre for Health Evaluation Outcome Sciences, St. Paul's Hospital, Vancouver, Canadian Province, Canada. 6. Surrey Memorial Hospital, Surrey, Canadian Province, Canada. 7. Complex Pain and Addiction Services, Vancouver General Hospital, Vancouver, Canadian Province, Canada.
Abstract
BACKGROUND AND OBJECTIVES: Buprenorphine/naloxone has been shown to be effective in the treatment of opioid use disorder. Due to its pharmacological properties, induction can be challenging, time-consuming, and result in sudden onset of withdrawal symptoms. METHODS: Retrospective case series (n = 2). RESULTS: Two patients with opioid use disorder were successfully started on buprenorphine/naloxone using a rapid micro-induction technique that did not cause precipitated withdrawal or require preceding cessation of other opioids. DISCUSSION AND CONCLUSIONS: These cases provide an alternative method for starting buprenorphine/naloxone that offers unique benefits compared to protocols previously described in the literature. SCIENTIFIC SIGNIFICANCE: This method can be used to minimize barriers to opioid agonist therapy. (Am J Addict 2019;28:262-265).
BACKGROUND AND OBJECTIVES:Buprenorphine/naloxone has been shown to be effective in the treatment of opioid use disorder. Due to its pharmacological properties, induction can be challenging, time-consuming, and result in sudden onset of withdrawal symptoms. METHODS: Retrospective case series (n = 2). RESULTS: Two patients with opioid use disorder were successfully started on buprenorphine/naloxone using a rapid micro-induction technique that did not cause precipitated withdrawal or require preceding cessation of other opioids. DISCUSSION AND CONCLUSIONS: These cases provide an alternative method for starting buprenorphine/naloxone that offers unique benefits compared to protocols previously described in the literature. SCIENTIFIC SIGNIFICANCE: This method can be used to minimize barriers to opioid agonist therapy. (Am J Addict 2019;28:262-265).
Authors: Victor M Tang; Jessica Lam-Shang-Leen; Thomas D Brothers; Keith Hansen; Alexander Caudarella; Wiplove Lamba; Tim Guimond Journal: Am J Addict Date: 2019-10-18
Authors: Denis Antoine; Andrew S Huhn; Eric C Strain; Gavin Turner; Jasmyne Jardot; Alexis S Hammond; Kelly E Dunn Journal: Am J Addict Date: 2020-06-23