Literature DB >> 3089837

Requirement of monohydroperoxy fatty acids for the oxygenation of 15LS-HETE by reticulocyte lipoxygenase.

H Kühn, R Wiesner, H Stender, T Schewe, V Z Lankin, A Nekrasov, S M Rapoport.   

Abstract

The lipoxygenase from reticulocytes oxygenates 15LS-HETE to 8-hydroperoxy-15-hydroxy-5,9,11,13-eicosatetraenoic acid and 5-hydroperoxy-15-hydroxy-6,8,11,13-eicosatetraenoic acid only in the presence of catalytic concentrations of monohydroperoxy fatty acids. During this reaction the hydroperoxy fatty acids are converted to more polar products including hydroxy fatty acids. From kinetic measurements of 15LS-HETE oxygenation it was calculated that 1 mol monohydroperoxy fatty acid is consumed during the oxygenation of about 9 mol 15LS-HETE.

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Year:  1986        PMID： 3089837     DOI： 10.1016/0014-5793(86)80752-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.

Authors:  Yuxiang Zheng; Alan R Brash
Journal:  J Biol Chem       Date:  2010-10-05       Impact factor: 5.157

2.  Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.

Authors:  Yuxiang Zheng; Alan R Brash
Journal:  J Biol Chem       Date:  2010-10-04       Impact factor: 5.157

3.  Macrophages actively accumulate malonyldialdehyde-modified but not enzymatically oxidized low density lipoprotein.

Authors:  V Z Lankin; A K Tikhaze; E M Kumskova
Journal:  Mol Cell Biochem       Date:  2012-02-04       Impact factor: 3.396

4.  5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.

Authors:  Abigail R Green; Cody Freedman; Jennyfer Tena; Benjamin E Tourdot; Benjamin Liu; Michael Holinstat; Theodore R Holman
Journal:  Biochemistry       Date:  2018-11-15       Impact factor: 3.162

5.  The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action.

Authors:  K Petrich; P Ludwig; H Kühn; T Schewe
Journal:  Biochem J       Date:  1996-03-15       Impact factor: 3.857

6.  In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2.

Authors:  Wan-Chen Tsai; Chakrapani Kalyanaraman; Adriana Yamaguchi; Michael Holinstat; Matthew P Jacobson; Theodore R Holman
Journal:  Biochemistry       Date:  2021-05-24       Impact factor: 3.162

Review 7.  The Biosynthesis of Enzymatically Oxidized Lipids.

Authors:  Ali A Hajeyah; William J Griffiths; Yuqin Wang; Andrew J Finch; Valerie B O'Donnell
Journal:  Front Endocrinol (Lausanne)       Date:  2020-11-19       Impact factor: 5.555
  7 in total

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