Changyi Wang1, Linghui Deng1, Shi Qiu2,3, Haiyang Bian4, Lu Wang1, Yuxiao Li1, Ming Liu1, Bo Wu5. 1. Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. 2. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. 3. Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, China. 4. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. 5. Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, Chengdu, China, dragonwb@126.com.
Abstract
BACKGROUND AND OBJECTIVE: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke (AIS). Serum albumin is known for its neuroprotective effects and is a marker of improved AIS patient outcomes. However, it is not known whether there is a relationship between serum albumin and HT. METHODS: AIS patients admitted to the Department of Neurology of West China Hospital from 2012 to 2016 were prospectively and consecutively enrolled. Baseline characteristics were collected. HT during hospitalization was diagnosed by brain imaging. Multivariate logistic regression analysis was performed to determine the relationship between serum albumin and HT. Confounding factors were identified by univariate analysis. Stratified logistic regression analysis was performed to identify effect modifiers. RESULTS: A total of 1996 AIS patients were recruited, of whom 135 (6.8%) developed HT. Serum albumin negatively correlated with HT. Patients in the upper serum albumin tertile (42.6-54.1 g/L) had a 46% lower risk of HT than patients in the lower tertile (19.3-39.1 g/L) after adjustment for potential confounders (OR 0.54, 95% CI 0.29-0.99, p = 0.04). Risk of HT decreased stepwise with higher serum albumin tertile (p for trend = 0.04). There was a significant interaction between serum albumin and age (p = 0.02), with no significant correlation between serum albumin and HT in patients over 60 years of age. CONCLUSIONS: Higher serum albumin is associated with lower HT risk in a dose-dependent manner in AIS patients younger than 60 years.
BACKGROUND AND OBJECTIVE: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke (AIS). Serum albumin is known for its neuroprotective effects and is a marker of improved AISpatient outcomes. However, it is not known whether there is a relationship between serum albumin and HT. METHODS:AISpatients admitted to the Department of Neurology of West China Hospital from 2012 to 2016 were prospectively and consecutively enrolled. Baseline characteristics were collected. HT during hospitalization was diagnosed by brain imaging. Multivariate logistic regression analysis was performed to determine the relationship between serum albumin and HT. Confounding factors were identified by univariate analysis. Stratified logistic regression analysis was performed to identify effect modifiers. RESULTS: A total of 1996 AISpatients were recruited, of whom 135 (6.8%) developed HT. Serum albumin negatively correlated with HT. Patients in the upper serum albumin tertile (42.6-54.1 g/L) had a 46% lower risk of HT than patients in the lower tertile (19.3-39.1 g/L) after adjustment for potential confounders (OR 0.54, 95% CI 0.29-0.99, p = 0.04). Risk of HT decreased stepwise with higher serum albumin tertile (p for trend = 0.04). There was a significant interaction between serum albumin and age (p = 0.02), with no significant correlation between serum albumin and HT in patients over 60 years of age. CONCLUSIONS: Higher serum albumin is associated with lower HT risk in a dose-dependent manner in AISpatients younger than 60 years.
Authors: Johnathan Abou-Fadel; Xiaoting Jiang; Akhil Padarti; Dinesh G Goswami; Mark Smith; Brian Grajeda; Muaz Bhalli; Alexander Le; Wendy E Walker; Jun Zhang Journal: Int J Mol Sci Date: 2022-08-26 Impact factor: 6.208