Jiajia Jiang1, Jia Cui2, Anping Wang2, Yiming Mu2, Yuxiang Yan1, Fen Liu1, Yuesong Pan3,4, Dongxue Li1, Wei Li1, Guangxu Liu1, Herbert Y Gaisano5, Jingtao Dou2, Yan He1,6. 1. Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China. 2. Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China. 3. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 4. China National Clinical Research Center for Neurologic Diseases, Beijing, China. 5. Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada. 6. Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
Abstract
OBJECTIVE: The relationship between age at natural menopause and type 2 diabetes mellitus (T2DM) has yielded conflicting results, particularly when confounded by the presence of obesity. We therefore aimed to examine the association between age at natural menopause and development of T2DM and the influence of postmenopausal obesity status on this association. DESIGN: The data for this study was derived from one center (Beijing) of the REACTION study. After screening through our inclusion and exclusion criteria, 2689 postmenopausal women who completed a 3-year follow-up were included. Logistic regression analysis was conducted to clarify the association of the age at natural menopause with the development of T2DM. RESULTS: After adjustment for potential confounders, there was no significant association between the age at natural menopause and development of T2DM for all subjects. However, when subjects were stratified along the postmenopausal obesity status at baseline, in the presence or absence of obesity, we found a surprising contradictory association in two subgroups: late menopause (age >50 years) was associated with an increased risk (OR, 1.45; 95% CI, 1.02 to 2.05) of developing T2DM in the postmenopausal group without obesity, whereas we found a reduced risk (OR, 0.43; 95% CI, 0.27 to 0.71) in the postmenopausal group with obesity. Moreover, we found that early menopausal women (age ≤45 years) with postmenopausal obesity had the highest risk (OR, 2.10; 95% CI, 1.11 to 4.00) of developing T2DM compared with all other postmenopausal women. CONCLUSIONS: Postmenopausal obesity status may influence the association of age at natural menopause and the development of T2DM.
OBJECTIVE: The relationship between age at natural menopause and type 2 diabetes mellitus (T2DM) has yielded conflicting results, particularly when confounded by the presence of obesity. We therefore aimed to examine the association between age at natural menopause and development of T2DM and the influence of postmenopausal obesity status on this association. DESIGN: The data for this study was derived from one center (Beijing) of the REACTION study. After screening through our inclusion and exclusion criteria, 2689 postmenopausal women who completed a 3-year follow-up were included. Logistic regression analysis was conducted to clarify the association of the age at natural menopause with the development of T2DM. RESULTS: After adjustment for potential confounders, there was no significant association between the age at natural menopause and development of T2DM for all subjects. However, when subjects were stratified along the postmenopausal obesity status at baseline, in the presence or absence of obesity, we found a surprising contradictory association in two subgroups: late menopause (age >50 years) was associated with an increased risk (OR, 1.45; 95% CI, 1.02 to 2.05) of developing T2DM in the postmenopausal group without obesity, whereas we found a reduced risk (OR, 0.43; 95% CI, 0.27 to 0.71) in the postmenopausal group with obesity. Moreover, we found that early menopausal women (age ≤45 years) with postmenopausal obesity had the highest risk (OR, 2.10; 95% CI, 1.11 to 4.00) of developing T2DM compared with all other postmenopausal women. CONCLUSIONS: Postmenopausal obesity status may influence the association of age at natural menopause and the development of T2DM.
Authors: Fatima Cody Stanford; Hellas Cena; Ginevra Biino; Olivia Umoren; Monik Jimenez; Marlene P Freeman; Aladdin H Shadyab; Robert A Wild; Catherine R Womack; Hailey R Banack; JoAnn E Manson Journal: Menopause Date: 2020-10 Impact factor: 3.310
Authors: Manuel Vasquez-Muñoz; Alexis Arce-Alvarez; Magdalena von Igel; Carlos Veliz; Gonzalo Ruiz-Esquide; Rodrigo Ramirez-Campillo; Cristian Alvarez; Robinson Ramirez-Velez; Fernando A Crespo; Mikel Izquierdo; Rodrigo Del Rio; David C Andrade Journal: Sci Rep Date: 2021-03-11 Impact factor: 4.379