Célia Costa1, Isabel Rosmaninho2, Arminda Guilherme2, José Ferreira2, Joana Antunes3, Ana Pina3, Sara Prates4, João Gaspar Marques4, Filomena Azevedo5, Ana Paula Cunha5, Celeste Brito6, António Massa7, João Teles Sousa8, Glória Cunha Velho, Inês Raposo9, Gabriela Marques Pinto10, Virgínia Sousa10, Ana Rodrigues Martins11. 1. Serviço de Imunoalergologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. 2. Serviço de Imunoalergologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia. Portugal. 3. Serviço de Dermatologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Portugal. 4. Serviço de Imunoalergologia. Hospital Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa. Portugal. 5. Serviço de Dermatologia. Centro Hospitalar de São João. Porto. Portugal. 6. Serviço de Dermatologia. Hospital de Braga. Braga. Portugal. 7. Serviço de Dermatologia. Centro Hospitalar de Vila Nova de Gaia. Vila Nova de Gaia. Portugal. 8. Serviço de Dermatologia. Hospital Egas Moniz. Centro Hospitalar Lisboa Ocidental. Lisboa. Portugal. 9. Serviço de Dermatologia. Centro Hospitalar do Porto. Porto. Portugal. 10. Serviço de Dermatologia. Hospital dos Capuchos. Centro Hospitalar Lisboa Central. Lisboa. Portugal. 11. Novartis Farma - Produtos Farmacêuticos, S.A. Porto Salvo. Portugal.
Abstract
INTRODUCTION: There is a paucity of information regarding chronic urticaria patients' care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study. MATERIAL AND METHODS: This is a non-interventional cohort study. Adult patients with a diagnosis of chronic urticaria with symptoms for at least two months, refractory to H1-antihistamines, consulting one of the 10 participating urticaria centers throughout Portugal have been included in the study. Baseline sociodemographic data, medical history, clinical parameters, medication, weekly urticaria activity score, and dermatology quality of life index have been collected. RESULTS: Seventy six patients were included, of which 76.3% were women. The majority of patients had a diagnosis of chronic spontaneous urticaria (88.2%) and 39.5% had angioedema. Around 91.0% of patients were medicated with non-sedative H1-antihistamines and 35.4% with a third line therapy. Median dermatology quality of life index was 5.0 and median weekly urticaria activity score was 13.0. DISCUSSION: The baseline results suggest that patients with chronic urticaria refractory to H1-antihistamines are being under-treated in the real-world setting. CONCLUSION: The AWARE study demonstrates the real impact of chronic urticaria on Portuguese patients refractory to H1-antihistamines treatment, and 30% report a very large or extremely large deleterious effect on their quality of life. The follow-up of these patients will allow evaluating strategies aimed at optimizing disease control.
INTRODUCTION: There is a paucity of information regarding chronic urticariapatients' care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticariapatients refractory to H1-antihistamines included in the AWARE study. MATERIAL AND METHODS: This is a non-interventional cohort study. Adult patients with a diagnosis of chronic urticaria with symptoms for at least two months, refractory to H1-antihistamines, consulting one of the 10 participating urticaria centers throughout Portugal have been included in the study. Baseline sociodemographic data, medical history, clinical parameters, medication, weekly urticaria activity score, and dermatology quality of life index have been collected. RESULTS: Seventy six patients were included, of which 76.3% were women. The majority of patients had a diagnosis of chronic spontaneous urticaria (88.2%) and 39.5% had angioedema. Around 91.0% of patients were medicated with non-sedative H1-antihistamines and 35.4% with a third line therapy. Median dermatology quality of life index was 5.0 and median weekly urticaria activity score was 13.0. DISCUSSION: The baseline results suggest that patients with chronic urticaria refractory to H1-antihistamines are being under-treated in the real-world setting. CONCLUSION: The AWARE study demonstrates the real impact of chronic urticaria on Portuguese patients refractory to H1-antihistamines treatment, and 30% report a very large or extremely large deleterious effect on their quality of life. The follow-up of these patients will allow evaluating strategies aimed at optimizing disease control.
Entities:
Keywords:
Chronic Disease; Cost of Illness; Health Resources; Portugal; Quality of Life; Urticaria
Authors: Pedro Lopes Ferreira; Margarida Gonçalo; José Alberto Ferreira; Ana Célia Costa; Ana Todo-Bom; Cristina Lopes Abreu; Ana Rita Travassos; Pedro Andrade; Ilaria Baiardini; Giorgio Walter Canonica Journal: Health Qual Life Outcomes Date: 2019-12-30 Impact factor: 3.186