Literature DB >> 30895984

Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics.

Zhangshuang Deng1, Nai-Kei Wong, Zhiyong Guo, Kun Zou, Youli Xiao, Yiqing Zhou.   

Abstract

Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.

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Year:  2019        PMID： 30895984     DOI： 10.1039/c9cc00256a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  The vital role of ATP citrate lyase in chronic diseases.

Authors:  Amrita Devi Khwairakpam; Kishore Banik; Sosmitha Girisa; Bano Shabnam; Mehdi Shakibaei; Lu Fan; Frank Arfuso; Javadi Monisha; Hong Wang; Xinliang Mao; Gautam Sethi; Ajaikumar B Kunnumakkara
Journal:  J Mol Med (Berl)       Date:  2019-12-19       Impact factor: 4.599

2.  In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.

Authors:  Maurizio D Baroni; Sonia Colombo; Olivier Libens; Rani Pallavi; Marco Giorgio; Enzo Martegani
Journal:  Apoptosis       Date:  2020-10       Impact factor: 4.677
  2 in total

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