Mats Hallgren1, Thi-Thuy-Dung Nguyen2, Neville Owen3, Brendon Stubbs4, Davy Vancampfort5, Andreas Lundin6, David Dunstan7, Rino Bellocco8, Ylva Trolle Lagerros9. 1. Assistant Professor, Department of Public Health Sciences, Karolinska Institutet, Sweden. 2. Research Assistant, Department of Public Health Sciences, Karolinska Institutet, Sweden. 3. Professor and Head of the Behavioural Epidemiology Laboratory, Baker Heart and Diabetes Institute, Swinburne University of Technology, Australia. 4. Clinical Lecturer, Physiotherapy Department, South London and Maudsley National Health Service Foundation Trust; and Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. 5. Lecturer, Department of Rehabilitation Sciences, University of Leuven; and University Psychiatric Center, Katholieke Universiteit Leuven, Belgium. 6. Project Coordinator, Department of Public Health Sciences, Karolinska Institutet, Sweden. 7. Professor and Head of the Physical Activity Laboratory, Baker Heart and Diabetes Institute; and Mary MacKillop Institute for Health Research, Australian Catholic University, Australia. 8. Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; and Department of Statistics and Quantitative Methods, University of Milano Bicocca, Italy. 9. Associate Professor, Obesity Center, Academic Specialist Center, Stockholm Health Services; and Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Sweden.
Abstract
BACKGROUND: Sedentary behaviour can be associated with poor mental health, but it remains unclear whether all types of sedentary behaviour have equivalent detrimental effects. AIMS: To model the potential impact on depression of replacing passive with mentally active sedentary behaviours and with light and moderate-to-vigorous physical activity. An additional aim was to explore these relationships by self-report data and clinician diagnoses of depression. METHOD: In 1997, 43 863 Swedish adults were initially surveyed and their responses linked to patient registers until 2010. The isotemporal substitution method was used to model the potential impact on depression of replacing 30 min of passive sedentary behaviour with equivalent durations of mentally active sedentary behaviour, light physical activity or moderate-to-vigorous physical activity. Outcomes were self-reported depression symptoms (cross-sectional analyses) and clinician-diagnosed incident major depressive disorder (MDD) (prospective analyses). RESULTS: Of 24 060 participants with complete data (mean age 49.2 years, s.d. 15.8, 66% female), 1526 (6.3%) reported depression symptoms at baseline. There were 416 (1.7%) incident cases of MDD during the 13-year follow-up. Modelled cross-sectionally, replacing 30 min/day of passive sedentary behaviour with 30 min/day of mentally active sedentary behaviour, light physical activity and moderate-to-vigorous activity reduced the odds of depression symptoms by 5% (odds ratio 0.95, 95% CI 0.94-0.97), 13% (odds ratio 0.87, 95% CI 0.76-1.00) and 19% (odds ratio 0.81, 95% CI 0.93-0.90), respectively. Modelled prospectively, substituting 30 min/day of passive with 30 min/day of mentally active sedentary behaviour reduced MDD risk by 5% (hazard ratio 0.95, 95% CI 0.91-0.99); no other prospective associations were statistically significant. CONCLUSIONS: Substituting passive with mentally active sedentary behaviours, light activity or moderate-to-vigorous activity may reduce depression risk in adults.
BACKGROUND: Sedentary behaviour can be associated with poor mental health, but it remains unclear whether all types of sedentary behaviour have equivalent detrimental effects. AIMS: To model the potential impact on depression of replacing passive with mentally active sedentary behaviours and with light and moderate-to-vigorous physical activity. An additional aim was to explore these relationships by self-report data and clinician diagnoses of depression. METHOD: In 1997, 43 863 Swedish adults were initially surveyed and their responses linked to patient registers until 2010. The isotemporal substitution method was used to model the potential impact on depression of replacing 30 min of passive sedentary behaviour with equivalent durations of mentally active sedentary behaviour, light physical activity or moderate-to-vigorous physical activity. Outcomes were self-reported depression symptoms (cross-sectional analyses) and clinician-diagnosed incident major depressive disorder (MDD) (prospective analyses). RESULTS: Of 24 060 participants with complete data (mean age 49.2 years, s.d. 15.8, 66% female), 1526 (6.3%) reported depression symptoms at baseline. There were 416 (1.7%) incident cases of MDD during the 13-year follow-up. Modelled cross-sectionally, replacing 30 min/day of passive sedentary behaviour with 30 min/day of mentally active sedentary behaviour, light physical activity and moderate-to-vigorous activity reduced the odds of depression symptoms by 5% (odds ratio 0.95, 95% CI 0.94-0.97), 13% (odds ratio 0.87, 95% CI 0.76-1.00) and 19% (odds ratio 0.81, 95% CI 0.93-0.90), respectively. Modelled prospectively, substituting 30 min/day of passive with 30 min/day of mentally active sedentary behaviour reduced MDD risk by 5% (hazard ratio 0.95, 95% CI 0.91-0.99); no other prospective associations were statistically significant. CONCLUSIONS: Substituting passive with mentally active sedentary behaviours, light activity or moderate-to-vigorous activity may reduce depression risk in adults.
Authors: Ida Marie Opdal; Bente Morseth; Bjørn-Helge Handegård; Kjersti R Lillevoll; Wendy Nilsen; Christopher Nielsen; Anne-Sofie Furberg; Simon Rosenbaum; Kamilla Rognmo Journal: BMJ Open Date: 2020-02-12 Impact factor: 2.692
Authors: Aaron Kandola; Gemma Lewis; David P J Osborn; Brendon Stubbs; Joseph F Hayes Journal: Lancet Psychiatry Date: 2020-02-11 Impact factor: 27.083