Literature DB >> 30894086

The BARA necessities of PtdIns 3-kinase activation in autophagy.

Chunmei Chang1,2, Lindsey N Young1,2,3, James H Hurley1,2,3.   

Abstract

Macroautophagy/autophagy is an evolutionarily conserved degradation system with fundamental biological functions. The activation of the class III phosphatidylinositol 3-kinase (PtdIns3K) complexes and the subsequent production of phosphatidylinositol 3-phosphate (PtdIns3P) are pivotal to autophagy. Using a combination of structural biology, biochemistry, and biophysics, we revealed how the non-catalytic subunit BECN1 serves as a membrane-binding switch in the regulation of PtdIns3K complexes and autophagy.

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Keywords:  Cryoelectron microscopy; HIV; Nef; Rubicon; Tat-BECN1 peptide; human immunodeficiency virus; hydrogen-deuterium exchange

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Year:  2019        PMID： 30894086      PMCID： PMC6526823          DOI： 10.1080/15548627.2019.1596501

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  1 in total

1.  Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.

Authors:  Chunmei Chang; Lindsey N Young; Kyle L Morris; Sören von Bülow; Johannes Schöneberg; Hitomi Yamamoto-Imoto; Yukako Oe; Kentaro Yamamoto; Shuhei Nakamura; Goran Stjepanovic; Gerhard Hummer; Tamotsu Yoshimori; James H Hurley
Journal:  Mol Cell       Date:  2018-12-20       Impact factor: 17.970
  1 in total
  3 in total

Review 1.  Development of an autophagy activator from Class III PI3K complexes, Tat-BECN1 peptide: Mechanisms and applications.

Authors:  Yanfei He; Huaqing Lu; Yuting Zhao
Journal:  Front Cell Dev Biol       Date:  2022-09-12

2.  HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner.

Authors:  Sergio Castro-Gonzalez; Yuhang Shi; Marta Colomer-Lluch; Ying Song; Kaitlyn Mowery; Sharilyn Almodovar; Anju Bansal; Frank Kirchhoff; Konstantin Sparrer; Chengyu Liang; Ruth Serra-Moreno
Journal:  Autophagy       Date:  2020-02-25       Impact factor: 16.016

3.  GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex.

Authors:  Yuting Zhao; Zhongju Zou; Daxiao Sun; Yue Li; Sangita C Sinha; Li Yu; Lynda Bennett; Beth Levine
Journal:  Autophagy       Date:  2020-11-23       Impact factor: 16.016
  3 in total

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