Marije Lamain-de Ruiter1, Anneke Kwee1, Christiana A Naaktgeboren2, Rebecca D Louhanepessy3, Inge De Groot4, Inge M Evers5, Floris Groenendaal6, Yolanda R Hering7, Anjoke J M Huisjes8, Cornel Kirpestein9, Wilma M Monincx10, Peter C J I Schielen11, Annewil Van 't Zelfde12, Charlotte M Van Oirschot13, Simone A Vankan-Buitelaar14, Mariska A A W Vonk15, Therese A Wiegers16, Joost J Zwart17, Karel G M Moons2, Arie Franx1, Maria P H Koster1,18. 1. a Department of Obstetrics, Division Woman and Baby , University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands. 2. b Julius Center for Health Sciences and Primary Care , University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands. 3. c Department of Medical Oncology , Netherlands Cancer Institute , Amsterdam , The Netherlands. 4. d Livive, Center for Obstetrics , Tilburg , The Netherlands. 5. e Department of Obstetrics , Meander Medical Center , Amersfoort , The Netherlands. 6. f Department of Neonatology, Division Woman and Baby , University Medical Center Utrecht, Utrecht University , Utrecht , The Netherlands. 7. g Department of Obstetrics , Zuwe Hofpoort Hospital , Woerden , The Netherlands. 8. h Department of Obstetrics , Gelre Hospital , Apeldoorn , The Netherlands. 9. i Department of Obstetrics , Hospital Rivierenland , Tiel , The Netherlands. 10. j Department of Obstetrics , St. Antonius Hospital , Nieuwegein , The Netherland. 11. k Center for Infectious Diseases Research, Diagnostics and Screening (IDS) , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands. 12. l Midwifery practice Verloskundigen Amersfoort , Amersfoort , The Netherlands. 13. m Department of Obstetrics , St Elisabeth Hospital , Tilburg , The Netherlands. 14. n Midwifery practice GCM , Maarssen , The Netherlands. 15. o Midwifery practice Het Wonder , Houten , The Netherlands. 16. p Netherlands Institute for health services research (NIVEL) , Utrecht , The Netherlands. 17. q Department of Obstetrics , Deventer Hospital , Deventer , The Netherlands. 18. r Department of Obstetrics and Gynecology, Erasmus Medical Center , University Medical Center Rotterdam , Rotterdam , the Netherlands.
Abstract
OBJECTIVE: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). METHODS: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. RESULTS: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. CONCLUSION: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
OBJECTIVE: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). METHODS:Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. RESULTS: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. CONCLUSION: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
Entities:
Keywords:
First trimester; external validation; preeclampsia; prognostic model
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