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Literature DB >> 3089271

The myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures.

Abstract

The effect of a highly purified human gamma IFN (r-gamma-IFN) on the growth of haemopoietic progenitors was examined in soft agar assays and in long-term bone marrow cultures. r-gamma-IFN reduced colony formation by progenitor cells of the granulocyte/macrophage lineage (GM-CFC), the erythroid lineage (BFU-E) and multipotent cells (GEMM-CFC), and suppressed haemopoiesis in long-term culture in a dose-related fashion. At high doses (1000 units/ml) r-gamma-IFN appeared to be toxic to the stromal cells of the bone marrow.

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Year: 1986 PMID： 3089271 DOI： 10.1111/j.1365-2141.1986.tb07529.x

Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998

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Cited

6 in total

The myelosuppressive effect of recombinant interferon gamma in short-term and long-term marrow cultures.

1. Myelopoiesis in vitro is suppressed by hepatitis A virus.

2. Treatment of Ph+ chronic myeloid leukemia by gamma interferon.

3. Sensitivity of Ph 1 + CFU-GM to human recombinant interferon alpha and gamma alone and in combination.

4. Gamma/delta receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis.

5. The long-term effects of MVPP chemotherapy for Hodgkin's disease on bone marrow function.

6. The growth of myelodysplastic bone marrow in long-term cultures.