Haydee M Linares Rosales1,2, Patricia Duguay-Drouin1,2, Louis Archambault1,2, Sam Beddar3, Luc Beaulieu1,2. 1. Département de physique, de génie physique et d'optique et Centre de recherche sur le cancer, Université Laval, Québec City, QC, Canada. 2. Département de radio-oncologie et Axe Oncologie du CRCHU de Québec, CHU de Québec - Université Laval, Québec City, QC, Canada. 3. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77003, USA.
Abstract
PURPOSE: This study is devoted to optimizing and characterizing the response of a multipoint plastic scintillator detector (mPSD) for application to in vivo dosimetry in high dose rate (HDR) brachytherapy. METHODS: An exhaustive analysis was carried out in order to obtain an optimized mPSD design that maximizes the scintillation light collection produced by the interaction of ionizing photons. More than 20 prototypes of mPSD were built and tested in order to determine the appropriate order of scintillators relative to the photodetector (distal, center, or proximal) as well as their length as a function of the scintillation light emitted. The available detecting elements are the BCF-60, BCF-12, and BCF-10 scintillators (Saint Gobain Crystals, Hiram, OH, USA), separated from each other by segments of Eska GH-4001 clear optical fibers (Mitsubishi Rayon Co., Ltd., Tokyo, Japan). The contribution of each scintillator to the total spectrum was determined by irradiations in the low energy range (<120 keV). For the best mPSD design, a numerical optimization was done in order to select the optical components [dichroic mirrors, filters, and photomultipliers tubes (PMTs)] that best match the light emission profile. Calculations were performed taking into account the measured scintillation spectrum and light yield, the manufacturer-reported transmission and attenuation of the optical components, and the experimentally characterized PMT noise. The optimized dosimetric system was used for HDR brachytherapy measurements. The system was independently controlled from the 192 Ir source via LabVIEW and read simultaneously using an NI-DAQ board. Dose measurements as a function of distance from the source were carried out according to TG-43U1 recommendations. The system performance was quantified in terms of signal to noise ratio (SNR) and signal to background ratio (SBR). RESULTS: For best overall light-yield emission, it was determined that BCF-60 should be placed at the distal position, BCF-12 in the center, and BCF-10 at the proximal position with respect to the photodetector. This configuration allowed for optimized light transmission through the collecting fiber and avoided inter-scintillator excitation and self-absorption effects. The optimal scintillator length found was of 3, 6, and 7 mm for BCF-10, BCF- 12, and BCF-60, respectively. The optimized luminescence system allowed for signal deconvolution using a multispectral approach, extracting the dose to each element while taking into account the Cerenkov stem effect. Differences between the mPSD measurements and TG-43U1 remain below 5% in the range of 0.5 to 6.5 cm from the source. The dosimetric system can properly differentiate the scintillation signal from the background for a wide range of dose rate conditions; the SNR was found to be above 5 for dose rates above 22 mGy/s while the minimum SBR measured was 1.8 at 6 mGy/s. CONCLUSION: Based on the spectral response at different conditions, an mPSD was constructed and optimized for HDR brachytherapy dosimetry. It is sensitive enough to allow multiple simultaneous measurements over a clinically useful distance range, up to 6.5 cm from the source. This study constitutes a baseline for future applications enabling real-time dose measurements and source position reporting over a wide range of dose rate conditions.
PURPOSE: This study is devoted to optimizing and characterizing the response of a multipoint plastic scintillator detector (mPSD) for application to in vivo dosimetry in high dose rate (HDR) brachytherapy. METHODS: An exhaustive analysis was carried out in order to obtain an optimized mPSD design that maximizes the scintillation light collection produced by the interaction of ionizing photons. More than 20 prototypes of mPSD were built and tested in order to determine the appropriate order of scintillators relative to the photodetector (distal, center, or proximal) as well as their length as a function of the scintillation light emitted. The available detecting elements are the BCF-60, BCF-12, and BCF-10 scintillators (Saint Gobain Crystals, Hiram, OH, USA), separated from each other by segments of Eska GH-4001 clear optical fibers (Mitsubishi Rayon Co., Ltd., Tokyo, Japan). The contribution of each scintillator to the total spectrum was determined by irradiations in the low energy range (<120 keV). For the best mPSD design, a numerical optimization was done in order to select the optical components [dichroic mirrors, filters, and photomultipliers tubes (PMTs)] that best match the light emission profile. Calculations were performed taking into account the measured scintillation spectrum and light yield, the manufacturer-reported transmission and attenuation of the optical components, and the experimentally characterized PMT noise. The optimized dosimetric system was used for HDR brachytherapy measurements. The system was independently controlled from the 192 Ir source via LabVIEW and read simultaneously using an NI-DAQ board. Dose measurements as a function of distance from the source were carried out according to TG-43U1 recommendations. The system performance was quantified in terms of signal to noise ratio (SNR) and signal to background ratio (SBR). RESULTS: For best overall light-yield emission, it was determined that BCF-60 should be placed at the distal position, BCF-12 in the center, and BCF-10 at the proximal position with respect to the photodetector. This configuration allowed for optimized light transmission through the collecting fiber and avoided inter-scintillator excitation and self-absorption effects. The optimal scintillator length found was of 3, 6, and 7 mm for BCF-10, BCF- 12, and BCF-60, respectively. The optimized luminescence system allowed for signal deconvolution using a multispectral approach, extracting the dose to each element while taking into account the Cerenkov stem effect. Differences between the mPSD measurements and TG-43U1 remain below 5% in the range of 0.5 to 6.5 cm from the source. The dosimetric system can properly differentiate the scintillation signal from the background for a wide range of dose rate conditions; the SNR was found to be above 5 for dose rates above 22 mGy/s while the minimum SBR measured was 1.8 at 6 mGy/s. CONCLUSION: Based on the spectral response at different conditions, an mPSD was constructed and optimized for HDR brachytherapy dosimetry. It is sensitive enough to allow multiple simultaneous measurements over a clinically useful distance range, up to 6.5 cm from the source. This study constitutes a baseline for future applications enabling real-time dose measurements and source position reporting over a wide range of dose rate conditions.
Authors: Mengyu Jia; Tae Jin Kim; Yong Yang; Lei Xing; Paul De Jean; Elliot Grafil; Cesare H Jenkins; Benjamin P Fahimian Journal: Phys Med Biol Date: 2020-11-17 Impact factor: 3.609