Literature DB >> 30891141

Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.

Sumedh Joshi1, Dmytro Fedoseyenko1, Nilkamal Mahanta1, Rodrigo G Ducati2, Mu Feng2, Vern L Schramm2, Tadhg P Begley1.   

Abstract

Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against H. pylori (IC50 = 1.8 ± 0.4 μM) and identifies MqnE as a promising target for antibiotic development.

Entities:  

Year:  2019        PMID： 30891141      PMCID： PMC6421580          DOI： 10.1021/acsmedchemlett.8b00649

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  30 in total

1.  Branched fatty acids inhibit the biosynthesis of menaquinone in Helicobacter pylori.

Authors:  Ruri Tanaka; Takao Kunisada; Nobuaki Kushida; Keiko Yamada; Shunsuke Ikeda; Motoyoshi Noike; Yuusuke Ono; Nobuya Itoh; Hideto Takami; Haruo Seto; Tohru Dairi
Journal:  J Antibiot (Tokyo)       Date:  2010-11-17       Impact factor: 2.649

2.  An alternative menaquinone biosynthetic pathway operating in microorganisms.

Authors:  Tomoshige Hiratsuka; Kazuo Furihata; Jun Ishikawa; Haruyuki Yamashita; Nobuya Itoh; Haruo Seto; Tohru Dairi
Journal:  Science       Date:  2008-09-19       Impact factor: 47.728

3.  Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain.

Authors:  Pavel Majer; Bunda Hin; Doris Stoermer; Jessica Adams; Weizheng Xu; Bridget R Duvall; Greg Delahanty; Qun Liu; Marigo J Stathis; Krystyna M Wozniak; Barbara S Slusher; Takashi Tsukamoto
Journal:  J Med Chem       Date:  2006-05-18       Impact factor: 7.446

Review 4.  Occurrence, biosynthesis and function of isoprenoid quinones.

Authors:  Beatrycze Nowicka; Jerzy Kruk
Journal:  Biochim Biophys Acta       Date:  2010-06-19

Review 5.  Vitamin K2 in bone metabolism and osteoporosis.

Authors:  Steven M Plaza; Davis W Lamson
Journal:  Altern Med Rev       Date:  2005-03

6.  A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori.

Authors:  Shanzhi Wang; Antti M Haapalainen; Funing Yan; Quan Du; Peter C Tyler; Gary B Evans; Agnes Rinaldo-Matthis; Rosemary L Brown; Gillian E Norris; Steven C Almo; Vern L Schramm
Journal:  Biochemistry       Date:  2012-08-22       Impact factor: 3.162

7.  Facile synthesis of alpha-substituted acrylate esters.

Authors:  Bunda Hin; Pavel Majer; Takashi Tsukamoto
Journal:  J Org Chem       Date:  2002-10-18       Impact factor: 4.354

8.  Natural transformation of an engineered Helicobacter pylori strain deficient in type II restriction endonucleases.

Authors:  Xue-Song Zhang; Martin J Blaser
Journal:  J Bacteriol       Date:  2012-04-20       Impact factor: 3.490

Review 9.  Vitamin K: the coagulation vitamin that became omnipotent.

Authors:  Ellen C M Cranenburg; Leon J Schurgers; Cees Vermeer
Journal:  Thromb Haemost       Date:  2007-07       Impact factor: 5.249

Review 10.  An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains.

Authors:  Tohru Dairi
Journal:  J Antibiot (Tokyo)       Date:  2009-06-26       Impact factor: 2.649
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  2 in total

Review 1.  Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems.

Authors:  Kenichi Yokoyama; Di Li; Haoran Pang
Journal:  ACS Bio Med Chem Au       Date:  2021-12-13

Review 2.  Helicobacter pylori treatment in the post-antibiotics era-searching for new drug targets.

Authors:  Paula Roszczenko-Jasińska; Marta Ilona Wojtyś; Elżbieta K Jagusztyn-Krynicka
Journal:  Appl Microbiol Biotechnol       Date:  2020-10-14       Impact factor: 4.813
  2 in total

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