Catherine S Forster1, Eleanor A Powell2, Barbara DeBurger2, Joshua Courter3, David B Haslam1, Joel E Mortensen4. 1. Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 2. Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 3. Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 4. Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Joel.Mortensen@cchmc.org.
Abstract
BACKGROUND: Patients with abnormalities of the genitourinary tract are at high risk for infections with antimicrobial-resistant pathogens. METHODS: All urine cultures ordered by members of the Division of Urology from four quarterly one-week periods were included. All gram-negative bacilli isolated were analyzed using the Check-Points Check-MDR CT103XL assay to identify the presence of genes associated with resistance to beta-lactam antibiotics. Association between the days of antibiotics and the presence of an ESBL-producing organism was determined. RESULTS: One hundred eleven positive cultures were included in this analysis, of which 5 (4.5%) contained ESBL-producing species. Days of systemic antibiotics within 30 days of urine culture was associated with an increased risk of isolating an ESBL-producing pathogen. CONCLUSION: The overall prevalence of ESBL-producing organisms is low in this cohort. The number of days of systemic antibiotics within 30 days of a urine culture was significantly associated with increased risk of isolating an ESBL-producing organism.
BACKGROUND:Patients with abnormalities of the genitourinary tract are at high risk for infections with antimicrobial-resistant pathogens. METHODS: All urine cultures ordered by members of the Division of Urology from four quarterly one-week periods were included. All gram-negative bacilli isolated were analyzed using the Check-Points Check-MDR CT103XL assay to identify the presence of genes associated with resistance to beta-lactam antibiotics. Association between the days of antibiotics and the presence of an ESBL-producing organism was determined. RESULTS: One hundred eleven positive cultures were included in this analysis, of which 5 (4.5%) contained ESBL-producing species. Days of systemic antibiotics within 30 days of urine culture was associated with an increased risk of isolating an ESBL-producing pathogen. CONCLUSION: The overall prevalence of ESBL-producing organisms is low in this cohort. The number of days of systemic antibiotics within 30 days of a urine culture was significantly associated with increased risk of isolating an ESBL-producing organism.
Authors: Frederik Boëtius Hertz; Kristian Schønning; Steen Christian Rasmussen; Pia Littauer; Jenny Dahl Knudsen; Anders Løbner-Olesen; Niels Frimodt-Møller Journal: Infect Dis (Lond) Date: 2015-11-02
Authors: Jonathan C Routh; Earl Y Cheng; J Christopher Austin; Michelle A Baum; Patricio C Gargollo; Richard W Grady; Adrienne R Herron; Steven S Kim; Shelly J King; Chester J Koh; Pangaja Paramsothy; Lisa Raman; Michael S Schechter; Kathryn A Smith; Stacy T Tanaka; Judy K Thibadeau; William O Walker; M Chad Wallis; John S Wiener; David B Joseph Journal: J Urol Date: 2016-07-27 Impact factor: 7.450