Literature DB >> 30889512

Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death.

Suresh K Joseph1, David M Booth2, Michael P Young2, György Hajnóczky2.   

Abstract

Physiological signaling by reactive oxygen species (ROS) and their pathophysiological role in cell death are well recognized. This review focuses on two ROS targets that are key to local Ca2+ signaling at the ER/mitochondrial interface - notably, inositol trisphosphate receptors (IP3Rs) and the mitochondrial calcium uniporter (MCU). Both transport systems are central to molecular mechanisms in cell survival and death. Methods for the measurement of the redox state of these proteins and for the detection of ROS nanodomains are described. Recent results on the redox regulation of these proteins are reviewed.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Ca(2+); IP(3); IP(3) receptor; Mitochondrial calcium uniporter; Reactive oxygen species; Redox regulation

Mesh：

Substances：

Year:  2019        PMID： 30889512     DOI： 10.1016/j.ceca.2019.02.006

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  11 in total

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