Literature DB >> 30889375

Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.

Xia Gao1, Jason W Locasale2, Michael A Reid1.   

Abstract

Altered metabolism is a common feature of new and recurring malignancy. In this issue of Cancer Cell, Reina-Campos and colleagues report upregulation of the serine, glycine, one-carbon (SGOC) metabolic network is required for neuroendocrine prostate cancer, a castration-resistant aggressive form of the disease, and presents a targetable vulnerability.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30889375      PMCID： PMC6425948          DOI： 10.1016/j.ccell.2019.02.014

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  8 in total

1.  Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Authors:  Oliver D K Maddocks; Dimitris Athineos; Eric C Cheung; Pearl Lee; Tong Zhang; Niels J F van den Broek; Gillian M Mackay; Christiaan F Labuschagne; David Gay; Flore Kruiswijk; Julianna Blagih; David F Vincent; Kirsteen J Campbell; Fatih Ceteci; Owen J Sansom; Karen Blyth; Karen H Vousden
Journal:  Nature       Date:  2017-04-19       Impact factor: 49.962

2.  Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.

Authors:  Li Ma; Yongzhen Tao; Angeles Duran; Victoria Llado; Anita Galvez; Jennifer F Barger; Elias A Castilla; Jing Chen; Tomoko Yajima; Aleksey Porollo; Mario Medvedovic; Laurence M Brill; David R Plas; Stefan J Riedl; Michael Leitges; Maria T Diaz-Meco; Adam D Richardson; Jorge Moscat
Journal:  Cell       Date:  2013-01-31       Impact factor: 41.582

3.  LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Authors:  Filippos Kottakis; Brandon N Nicolay; Ahlima Roumane; Rahul Karnik; Hongcang Gu; Julia M Nagle; Myriam Boukhali; Michele C Hayward; Yvonne Y Li; Ting Chen; Marc Liesa; Peter S Hammerman; Kwok Kin Wong; D Neil Hayes; Orian S Shirihai; Nicholas J Dyson; Wilhelm Haas; Alexander Meissner; Nabeel Bardeesy
Journal:  Nature       Date:  2016-10-31       Impact factor: 49.962

4.  Characterization of the usage of the serine metabolic network in human cancer.

Authors:  Mahya Mehrmohamadi; Xiaojing Liu; Alexander A Shestov; Jason W Locasale
Journal:  Cell Rep       Date:  2014-11-06       Impact factor: 9.423

Review 5.  Targeting Metabolism for Cancer Therapy.

Authors:  Alba Luengo; Dan Y Gui; Matthew G Vander Heiden
Journal:  Cell Chem Biol       Date:  2017-09-21       Impact factor: 8.116

6.  Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.

Authors:  Sheng Yu Ku; Spencer Rosario; Yanqing Wang; Ping Mu; Mukund Seshadri; Zachary W Goodrich; Maxwell M Goodrich; David P Labbé; Eduardo Cortes Gomez; Jianmin Wang; Henry W Long; Bo Xu; Myles Brown; Massimo Loda; Charles L Sawyers; Leigh Ellis; David W Goodrich
Journal:  Science       Date:  2017-01-06       Impact factor: 47.728

7.  Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.

Authors:  Samantha J Mentch; Mahya Mehrmohamadi; Lei Huang; Xiaojing Liu; Diwakar Gupta; Dwight Mattocks; Paola Gómez Padilla; Gene Ables; Marcas M Bamman; Anna E Thalacker-Mercer; Sailendra N Nichenametla; Jason W Locasale
Journal:  Cell Metab       Date:  2015-09-24       Impact factor: 27.287

8.  Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.

Authors:  Michael A Reid; Annamarie E Allen; Shiyu Liu; Maria V Liberti; Pei Liu; Xiaojing Liu; Ziwei Dai; Xia Gao; Qian Wang; Ying Liu; Luhua Lai; Jason W Locasale
Journal:  Nat Commun       Date:  2018-12-21       Impact factor: 14.919
  8 in total
  4 in total

1.  In Silico Prediction of Metabolic Fluxes in Cancer Cells with Altered S-adenosylmethionine Decarboxylase Activity.

Authors:  Olga Dotsenko; Dmytro Shtofel
Journal:  Cell Biochem Biophys       Date:  2020-10-11       Impact factor: 2.194

2.  Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer.

Authors:  Marie-Lisa Eich; Maria Del Carmen Rodriguez Pena; Darshan Shimoga Chandrashekar; Alcides Chaux; Sumit Agarwal; Jennifer B Gordetsky; James E Ferguson; Guru P Sonpavde; George J Netto; Sooryanarayana Varambally
Journal:  Transl Oncol       Date:  2019-08-08       Impact factor: 4.243

Review 3.  Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer.

Authors:  Carlo Ganini; Ivano Amelio; Riccardo Bertolo; Eleonora Candi; Angela Cappello; Chiara Cipriani; Alessandro Mauriello; Carla Marani; Gerry Melino; Manuela Montanaro; Maria Emanuela Natale; Giuseppe Tisone; Yufang Shi; Ying Wang; Pierluigi Bove
Journal:  Discov Oncol       Date:  2021-10-27

4.  CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer.

Authors:  Molishree Joshi; Jihye Kim; Angelo D'Alessandro; Emily Monk; Kimberley Bruce; Hanan Elajaili; Eva Nozik-Grayck; Andrew Goodspeed; James C Costello; Isabel R Schlaepfer
Journal:  Cancers (Basel)       Date:  2020-11-18       Impact factor: 6.575
  4 in total

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