| Literature DB >> 30889293 |
Federica Ungaro1,2, Piergiuseppe Colombo3, Luca Massimino4, Giovanni Stefano Ugolini5, Carmen Correale1, Marco Rasponi5, Valentina Garlatti2, Federica Rubbino2, Carlotta Tacconi6, Paola Spaggiari3, Antonino Spinelli2,7, Michele Carvello2,7, Matteo Sacchi2,7, Salvatore Spanò1,2, Stefania Vetrano1,2, Alberto Malesci8,9, Laurent Peyrin-Biroulet10, Silvio Danese1,2, Silvia D'Alessio1,2.
Abstract
Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix. Here we provide the first evidence that CRC-associated lymphatic endothelium displays a distinct matrisome-associated transcriptomic signature, which distinguishes them from healthy intestinal lymphatics. We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression. Our data provide new insights into lymphatic contribution to CRC growth, aside from their conventional role as conduits of metastasis.Entities:
Keywords: colorectal cancer; extracellular matrix; gene expression profile; lymphatic endothelium; matrisome
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Year: 2019 PMID： 30889293 DOI： 10.1002/ijc.32286
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396