Literature DB >> 3088929

Guanabenz as inhibitor of copper-containing amine oxidases.

G Banchelli, B Bertocci, L Raimondi, G Soldani, M Del Tacca, F Buffoni.   

Abstract

The effects of guanabenz on some copper containing amine oxidases are described. Guanabenz 'in vitro' inhibits pig plasma benzylamine oxidase with a IC50 M 5.1 +/- 0.8 X 10(-6) M. It also inhibits pig kidney diamine oxidase and rat liver mitochondrial monoamine oxidase at higher concentrations. The significance of this property of guanabenz is discussed.

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Year:  1986        PMID： 3088929     DOI： 10.1007/bf01987979

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  BENZYLAMINE OXIDASE AND HISTAMINASE: PURIFICATION AND CRYSTALLIZATION OF AN ENZYME FROM PIG PLASMA.

Authors:  F BUFFONI; H BLASCHKO
Journal:  Proc R Soc Lond B Biol Sci       Date:  1964-12-15

2.  Comparison of the 14-C-putrescine assay with the NADH test for the determination of diamine oxidase: description of a standard procedure with a high precision and an improved accuracy.

Authors:  J Kusche; H Richter; R Hesterberg; J Schmidt; W Lorenz
Journal:  Agents Actions       Date:  1973-10

3.  A lysyl oxidase with histaminase activity in the pig aorta.

Authors:  F Buffoni; L Raimondi
Journal:  Agents Actions       Date:  1981-04

4.  Enzyme activity of an amine oxidase to pargyline in the cardiovascular system of hypertensive rats.

Authors:  M del Carmen Urdin; J A Fuentes
Journal:  Biochem Pharmacol       Date:  1983-08-01       Impact factor: 5.858

5.  Active-sitve titration of pig plasma benzylamine oxidase with phenylhydrazine.

Authors:  F Buffoni; G Ignesti
Journal:  Biochem J       Date:  1975-02       Impact factor: 3.857

6.  3-hydrazinopyridazine derivatives as inhibitors of the copper containing amine oxidases.

Authors:  F Buffoni; G Ignesti; R Pirisino
Journal:  Farmaco Sci       Date:  1977-06

7.  Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO).

Authors:  M A Beaven; N B Roderick
Journal:  Biochem Pharmacol       Date:  1980-10-15       Impact factor: 5.858

Review 8.  Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension.

Authors:  B Holmes; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1983-09       Impact factor: 9.546

9.  3-Hydrazinopyridazine derivatives as inhibitors of pyridoxal-phosphate dependent enzymes.

Authors:  F Buffoni; C Carpi; G Banchelli Soldaini; L Raimondi
Journal:  Farmaco Sci       Date:  1980-10
  9 in total
  1 in total

1.  Prediction and validation of enzyme and transporter off-targets for metformin.

Authors:  Sook Wah Yee; Lawrence Lin; Matthew Merski; Michael J Keiser; Aakash Gupta; Youcai Zhang; Huan-Chieh Chien; Brian K Shoichet; Kathleen M Giacomini
Journal:  J Pharmacokinet Pharmacodyn       Date:  2015-09-03       Impact factor: 2.745
  1 in total

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