Literature DB >> 308887

Effect of piperazine on central and peripheral cholinergic synapses of the frog.

A Nistri, M S Arenson.   

Abstract

The anthelmintic agent piperazine did not antagonize carbachol-induced depolarizations of the frog sartorius muscle but depressed root potentials and acetylcholine release from the frog spinal cord. We suggest that piperazine has a presynaptic site of action at central cholinergic nerve-terminals.

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Year:  1978        PMID： 308887     DOI： 10.1007/bf01915338

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  The antagonism between tubocurarine and substances which depolarize the motor end-plate.

Authors:  D H JENKINSON
Journal:  J Physiol       Date:  1960-07       Impact factor: 5.182

2.  Investigations on the action of piperazine on Ascaris lumbricoides.

Authors:  S NORTON; E J DE BEER
Journal:  Am J Trop Med Hyg       Date:  1957-09       Impact factor: 2.345

3.  The effects of depolarization of motor nerve terminals upon the release of transmitter by nerve impulses.

Authors:  J I Hubbard; W D Willis
Journal:  J Physiol       Date:  1968-02       Impact factor: 5.182

4.  Piperazine neurotoxicity: "worm wobble".

Authors:  A C Parsons
Journal:  Br Med J       Date:  1971-12-25

5.  A comparative study of the action of gamma-aminobutyric acid and piperazine on the lobster muscle fibre and the frog spinal cord.

Authors:  A Constanti; A Nistri
Journal:  Br J Pharmacol       Date:  1976-07       Impact factor: 8.739

6.  The effect of electrical stimulation and drugs on the release of acetylcholine from the frog spinal cord.

Authors:  A Nistri
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-06       Impact factor: 3.000

7.  Further investigations into the effects of baclofen (Lioresal) on the isolated spinal cord.

Authors:  A Nistri
Journal:  Experientia       Date:  1975-09-15

8.  Some pharmacological properties of piperazine.

Authors:  P A Mason; G Sturman
Journal:  Br J Pharmacol       Date:  1972-02       Impact factor: 8.739

9.  Cholinergic transmission in the frog spinal cord.

Authors:  J F Mitchell; J W Phillis
Journal:  Br J Pharmacol Chemother       Date:  1962-12

10.  Aspects of the pharmacology of a new anthelmintic: pyrantel.

Authors:  M L Aubry; P Cowell; M J Davey; S Shevde
Journal:  Br J Pharmacol       Date:  1970-02       Impact factor: 8.739
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  1 in total

1.  The effects of piperazine on rat sympathetic neurones.

Authors:  J D Connor; A Constanti; P M Dunn; A Forward; A Nistri
Journal:  Br J Pharmacol       Date:  1981-10       Impact factor: 8.739
  1 in total

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