Literature DB >> 30888117

Precision medicine in Thailand.

Vorasuk Shotelersuk1,2, Sissades Tongsima3, Manop Pithukpakorn4,5, Jakris Eu-Ahsunthornwattana6,7, Surakameth Mahasirimongkol8.   

Abstract

Extraordinary advances in high throughput next generation sequencing (NGS) technology and bioinformatics are the main thrust that transforms the current state of healthcare into the era of precision medicine where clinical practice takes individual variability into account. Here, we summarize the current status of the infrastructure we have and the adoption of precision medicine in Thailand in four spheres: rare diseases, oncology, pharmacogenomics, and noncommunicable diseases. Moreover, we provide our perspectives to the future of precision medicine in Thailand, especially the manpower and ethical, legal, and social issues. We believe that with decreasing costs of NGS, increasing ability to interpret the genomic data, a greater number of actionable and available treatments, implementation of precision medicine at the public health level is not a matter of if but when.
© 2019 Wiley Periodicals, Inc.

Keywords:  Thailand; noncommunicable diseases; pharmacogenomics; precision medicine; precision oncology; rare diseases

Mesh:

Year:  2019        PMID: 30888117     DOI: 10.1002/ajmg.c.31694

Source DB:  PubMed          Journal:  Am J Med Genet C Semin Med Genet        ISSN: 1552-4868            Impact factor:   3.908


  6 in total

Review 1.  Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.

Authors:  Cyrine E Haidar; Kristine R Crews; James M Hoffman; Mary V Relling; Kelly E Caudle
Journal:  Annu Rev Genomics Hum Genet       Date:  2022-05-10       Impact factor: 9.340

Review 2.  Co-Clinical Trials: An Innovative Drug Development Platform for Cholangiocarcinoma.

Authors:  Brinda Balasubramanian; Simran Venkatraman; Kyaw Zwar Myint; Tavan Janvilisri; Kanokpan Wongprasert; Supeecha Kumkate; David O Bates; Rutaiwan Tohtong
Journal:  Pharmaceuticals (Basel)       Date:  2021-01-11

3.  Genotypic and phenotypic landscapes of 51 pharmacogenes derived from whole-genome sequencing in a Thai population.

Authors:  Natnicha Wankaew; Pajaree Chariyavilaskul; Monpat Chamnanphon; Adjima Assawapitaksakul; Wanna Chetruengchai; Monnat Pongpanich; Vorasuk Shotelersuk
Journal:  PLoS One       Date:  2022-02-17       Impact factor: 3.240

4.  Public R&D Projects-Based Investment and Collaboration Framework for an Overarching South Korean National Strategy of Personalized Medicine.

Authors:  Doyeon Lee; Keunhwan Kim
Journal:  Int J Environ Res Public Health       Date:  2022-01-24       Impact factor: 3.390

5.  Genomic findings of hypertrophic and dilated cardiomyopathy characterized in a Thai clinical genetics service.

Authors:  Objoon Trachoo; Teerapat Yingchoncharoen; Tawai Ngernsritrakul; Nareenart Iemwimangsa; Bhakbhoom Panthan; Sommon Klumsathian; Sasima Srisukh; Anucha Mukdadilok; Sithakom Phusanti; Angkana Charoenyingwattana; Takol Chareonsirisuthigul; Wasun Chantratita; Tarinee Tangcharoen
Journal:  PLoS One       Date:  2022-09-27       Impact factor: 3.752

Review 6.  Rare versus common diseases: a false dichotomy in precision medicine.

Authors:  Brian Hon Yin Chung; Jeffrey Fong Ting Chau; Gane Ka-Shu Wong
Journal:  NPJ Genom Med       Date:  2021-02-24       Impact factor: 8.617

  6 in total

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