Literature DB >> 30887114

[LHON-Treatment option despite poor initial visual acuity?]

A Rickmann1, L Wocker2, L-J Damm2, C Ivanescu2, P Szurman2, N Pérez Guerra2.   

Abstract

A case of Leber's hereditary optic neuropathy is reported in order to draw attention to this rare mitochondrial disease in the differential diagnostics and to show current treatment options. In this case despite very poor initial visual acuity and late start of treatment an improvement of visual acuity relevant for the patient could be achieved.

Entities:  

Keywords:  Idebenone; Leber’s hereditary optic neuropathy; Nervus opticus; Raxone; mitochondrial disease

Mesh：

Year:  2019        PMID： 30887114     DOI： 10.1007/s00347-019-0864-8

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN： 0941-293X            Impact factor:   1.059


  38 in total

1.  The epidemiology of Leber hereditary optic neuropathy in the North East of England.

Authors:  P Yu-Wai-Man; P G Griffiths; D T Brown; N Howell; D M Turnbull; P F Chinnery
Journal:  Am J Hum Genet       Date:  2002-01-07       Impact factor: 11.025

2.  Ophthalmologic findings in Leber hereditary optic neuropathy, with special reference to mtDNA mutations.

Authors:  E K Nikoskelainen; K Huoponen; V Juvonen; T Lamminen; K Nummelin; M L Savontaus
Journal:  Ophthalmology       Date:  1996-03       Impact factor: 12.079

Review 3.  Leber hereditary optic neuropathy: clinical and molecular genetic findings.

Authors:  K Huoponen
Journal:  Neurogenetics       Date:  2001-07       Impact factor: 2.660

4.  Variable pattern of visual recovery of Leber's hereditary optic neuropathy.

Authors:  M Nakamura; M Yamamoto
Journal:  Br J Ophthalmol       Date:  2000-05       Impact factor: 4.638

5.  Leber's "plus": neurological abnormalities in patients with Leber's hereditary optic neuropathy.

Authors:  E K Nikoskelainen; R J Marttila; K Huoponen; V Juvonen; T Lamminen; P Sonninen; M L Savontaus
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-08       Impact factor: 10.154

6.  Idebenone: A Review in Leber's Hereditary Optic Neuropathy.

Authors:  Katherine A Lyseng-Williamson
Journal:  Drugs       Date:  2016-05       Impact factor: 9.546

7.  Gene-environment interactions in Leber hereditary optic neuropathy.

Authors:  Matthew Anthony Kirkman; Patrick Yu-Wai-Man; Alex Korsten; Miriam Leonhardt; Konstantin Dimitriadis; Ireneaus F De Coo; Thomas Klopstock; Patrick Francis Chinnery
Journal:  Brain       Date:  2009-06-12       Impact factor: 13.501

8.  Effects of idebenone on color vision in patients with leber hereditary optic neuropathy.

Authors:  Guenther Rudolph; Konstantinos Dimitriadis; Boriana Büchner; Suzette Heck; Jasmina Al-Tamami; Florian Seidensticker; Christian Rummey; Mika Leinonen; Thomas Meier; Thomas Klopstock
Journal:  J Neuroophthalmol       Date:  2013-03       Impact factor: 3.042

9.  Grand rounds: could occupational exposure to n-hexane and other solvents precipitate visual failure in leber hereditary optic neuropathy?

Authors:  Valerio Carelli; Flavia Franceschini; Silvia Venturi; Piero Barboni; Giacomo Savini; Giuseppe Barbieri; Ettore Pirro; Chiara La Morgia; Maria L Valentino; Francesca Zanardi; Francesco S Violante; Stefano Mattioli
Journal:  Environ Health Perspect       Date:  2007-01       Impact factor: 9.031

10.  International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy.

Authors:  Valerio Carelli; Michele Carbonelli; Irenaeus F de Coo; Aki Kawasaki; Thomas Klopstock; Wolf A Lagrèze; Chiara La Morgia; Nancy J Newman; Christophe Orssaud; Jan Willem R Pott; Alfredo A Sadun; Judith van Everdingen; Catherine Vignal-Clermont; Marcela Votruba; Patrick Yu-Wai-Man; Piero Barboni
Journal:  J Neuroophthalmol       Date:  2017-12       Impact factor: 3.042
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