| Literature DB >> 30886422 |
Linyu Geng1, Xiaojun Tang1, Kangxing Zhou1, Dandan Wang1, Shiying Wang1, Genhong Yao1, Weiwei Chen1, Xiang Gao2, Wanjun Chen3, Songtao Shi4, Nan Shen5, Xuebing Feng6, Lingyun Sun7.
Abstract
Mesenchymal stem cells (MSCs) are critical for immune regulation. Although several microRNAs (miRNAs) have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function, the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear. Here, we show that patients with systemic lupus erythematosus (SLE) display a unique miRNA signature in bone marrow-derived MSCs (BMSCs) compared with normal controls, among which miR-663 is closely associated with SLE disease activity. MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper (Tfh) cells and upregulation of regulatory T (Treg) cells by targeting transforming growth factor β1 (TGF-β1). MiR-663 overexpression weakens the therapeutic effect of BMSCs, while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice. Thus, miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus.Entities:
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Year: 2018 PMID： 30886422 PMCID： PMC6460486 DOI： 10.1038/cmi.2018.1
Source DB: PubMed Journal: Cell Mol Immunol ISSN： 1672-7681 Impact factor: 11.530