Emily Jeffery1,2, Y C Gary Lee3,4,5, Robert U Newton1,2,6, Philippa Lyons-Wall2, Joanne McVeigh7,8, Anna K Nowak5,9,10, Hui Min Cheah5, Bella Nguyen9, Deirdre B Fitzgerald3, Jenette Creaney4,5,10, Leon Straker11, Carolyn J Peddle-McIntyre12,13. 1. Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia. 2. School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. 3. Respiratory Department, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia. 4. Institute for Respiratory Health, Nedlands, WA, 6009, Australia. 5. Medical School, University of Western Australia, Crawley, WA, Australia. 6. School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD, Australia. 7. School of Occupational Therapy, Speech Therapy and Social Work, Curtin University, Perth, WA, Australia. 8. Movement Physiology Laboratory, School of Physiology, University of Witwatersrand, Johannesburg, 2000, South Africa. 9. Medical Oncology Department, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. 10. National Centre for Asbestos Related Diseases, University of Western Australia, Crawley, WA, Australia. 11. School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia. 12. Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia. c.mcintyre@ecu.edu.au. 13. School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. c.mcintyre@ecu.edu.au.
Abstract
BACKGROUND/ OBJECTIVES: Malignant pleural mesothelioma (MPM) is an incurable cancer and optimizing daily physical activity and quality of life are key goals of patient management. Little is known about the prevalence of pre-sarcopenia and malnutrition in MPM or their associations with patient outcomes. This study aimed to determine the prevalence of pre-sarcopenia and malnutrition in MPM and investigate if activity levels and quality of life differed according to body composition and nutritional status. SUBJECTS/ METHODS: Patients with a diagnosis of MPM were recruited. Pre-sarcopenia was defined as low appendicular skeletal muscle mass (≤ 7.26 kg/m2 for men and ≤ 5.45 kg/m2 for women), measured by dual energy X-ray absorptiometry. Malnutrition was defined as a rating of B or C on the Patient-Generated Subjective Global Assessment. Outcome measures included objective activity levels (Actigraph GT3X) and health-related quality of life (HRQoL; Functional Assessment of Cancer Therapy General). RESULTS: Sixty-one people participated (79% male, median age 69 [IQR 62-74] years and median BMI 25.8 [IQR 24.3-28.4] kg/m2). Fifty-four percent were pre-sarcopenic and 38% were malnourished. Percent of time spent in light activity/day was lower in participants with pre-sarcopenia compared with non-sarcopenic participants (median 25.4 [IQR 19.8-32.1]% vs. 32.3 [27.1-35.6]%; p = 0.008). Participants with malnutrition had poorer HRQoL than well-nourished participants (mean 69.0 (16.3) vs. 84.4 (13.3); p < 0.001). CONCLUSION: Participants with MPM had high rates of pre-sarcopenia and malnutrition. Pre-sarcopenia was associated with poorer activity levels, whilst malnutrition was associated with poorer quality of life. Interventions that aim to address reduced muscle mass and weight loss, should be tested in MPM to assess their impact on patient outcomes.
BACKGROUND/ OBJECTIVES:Malignant pleural mesothelioma (MPM) is an incurable cancer and optimizing daily physical activity and quality of life are key goals of patient management. Little is known about the prevalence of pre-sarcopenia and malnutrition in MPM or their associations with patient outcomes. This study aimed to determine the prevalence of pre-sarcopenia and malnutrition in MPM and investigate if activity levels and quality of life differed according to body composition and nutritional status. SUBJECTS/ METHODS:Patients with a diagnosis of MPM were recruited. Pre-sarcopenia was defined as low appendicular skeletal muscle mass (≤ 7.26 kg/m2 for men and ≤ 5.45 kg/m2 for women), measured by dual energy X-ray absorptiometry. Malnutrition was defined as a rating of B or C on the Patient-Generated Subjective Global Assessment. Outcome measures included objective activity levels (Actigraph GT3X) and health-related quality of life (HRQoL; Functional Assessment of Cancer Therapy General). RESULTS: Sixty-one people participated (79% male, median age 69 [IQR 62-74] years and median BMI 25.8 [IQR 24.3-28.4] kg/m2). Fifty-four percent were pre-sarcopenic and 38% were malnourished. Percent of time spent in light activity/day was lower in participants with pre-sarcopenia compared with non-sarcopenicparticipants (median 25.4 [IQR 19.8-32.1]% vs. 32.3 [27.1-35.6]%; p = 0.008). Participants with malnutrition had poorer HRQoL than well-nourished participants (mean 69.0 (16.3) vs. 84.4 (13.3); p < 0.001). CONCLUSION:Participants with MPM had high rates of pre-sarcopenia and malnutrition. Pre-sarcopenia was associated with poorer activity levels, whilst malnutrition was associated with poorer quality of life. Interventions that aim to address reduced muscle mass and weight loss, should be tested in MPM to assess their impact on patient outcomes.
Authors: Emily Jeffery; Y C Gary Lee; Robert U Newton; Philippa Lyons-Wall; Joanne McVeigh; Deirdre B Fitzgerald; Leon Straker; Carolyn J Peddle-McIntyre Journal: Eur J Clin Nutr Date: 2022-01-17 Impact factor: 4.884
Authors: Scott A Fisher; Carolyn J Peddle-McIntyre; Kimberley Burton; Robert U Newton; Elly Marcq; Richard A Lake; Anna K Nowak Journal: BMC Res Notes Date: 2020-09-15