Literature DB >> 30885898

In Vitro Activity of Combinations of Zinc Chelators with Amphotericin B and Posaconazole against Six Mucorales Species.

Florencia Leonardelli1,2, Daiana Macedo1,2, Catiana Dudiuk1,2, Laura Theill1, Matias S Cabeza1,2, Soledad Gamarra1, Guillermo Garcia-Effron3,2.   

Abstract

Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Mucorales; antifungal susceptibility testing; posaconazole; zinc chelators

Year:  2019        PMID： 30885898      PMCID： PMC6496101          DOI： 10.1128/AAC.00266-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Combination therapy for mucormycosis: why, what, and how?

Authors:  Brad Spellberg; Ashraf Ibrahim; Emmanuel Roilides; Russel E Lewis; Olivier Lortholary; George Petrikkos; Dimitrios P Kontoyiannis; Thomas J Walsh
Journal:  Clin Infect Dis       Date:  2012-02       Impact factor: 9.079

Review 2.  The oxidative stress of zinc deficiency.

Authors:  David J Eide
Journal:  Metallomics       Date:  2011-07-26       Impact factor: 4.526

Review 3.  Antifungal resistance in mucorales.

Authors:  E Dannaoui
Journal:  Int J Antimicrob Agents       Date:  2017-08-09       Impact factor: 5.283

Review 4.  Combination therapy for the treatment of pulmonary mold infections.

Authors:  Matthew William McCarthy; Vidmantas Petraitis; Thomas J Walsh
Journal:  Expert Rev Respir Med       Date:  2017-05-09       Impact factor: 3.772

5.  Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.

Authors:  Paris Laskaris; Ahmad Atrouni; José Antonio Calera; Christophe d'Enfert; Hélène Munier-Lehmann; Jean-Marc Cavaillon; Jean-Paul Latgé; Oumaïma Ibrahim-Granet
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

6.  Genetic identification of the main opportunistic Mucorales by PCR-restriction fragment length polymorphism.

Authors:  M Machouart; J Larché; K Burton; J Collomb; P Maurer; A Cintrat; M F Biava; S Greciano; A F A Kuijpers; N Contet-Audonneau; G S de Hoog; A Gérard; B Fortier
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948

7.  Targeting zinc homeostasis to combat Aspergillus fumigatus infections.

Authors:  Rocío Vicentefranqueira; Jorge Amich; Paris Laskaris; Oumaima Ibrahim-Granet; Jean P Latgé; Héctor Toledo; Fernando Leal; José A Calera
Journal:  Front Microbiol       Date:  2015-02-27       Impact factor: 5.640

Review 8.  Therapy of Mucormycosis.

Authors:  Nikolaos V Sipsas; Maria N Gamaletsou; Amalia Anastasopoulou; Dimitrios P Kontoyiannis
Journal:  J Fungi (Basel)       Date:  2018-07-31

9.  ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013.

Authors:  O A Cornely; S Arikan-Akdagli; E Dannaoui; A H Groll; K Lagrou; A Chakrabarti; F Lanternier; L Pagano; A Skiada; M Akova; M C Arendrup; T Boekhout; A Chowdhary; M Cuenca-Estrella; T Freiberger; J Guinea; J Guarro; S de Hoog; W Hope; E Johnson; S Kathuria; M Lackner; C Lass-Flörl; O Lortholary; J F Meis; J Meletiadis; P Muñoz; M Richardson; E Roilides; A M Tortorano; A J Ullmann; A van Diepeningen; P Verweij; G Petrikkos
Journal:  Clin Microbiol Infect       Date:  2014-04       Impact factor: 8.067

Review 10.  Fungal zinc metabolism and its connections to virulence.

Authors:  Charley C Staats; Lívia Kmetzsch; Augusto Schrank; Marilene H Vainstein
Journal:  Front Cell Infect Microbiol       Date:  2013-10-14       Impact factor: 5.293
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  12 in total

Review 1.  Current Treatment Options for COVID-19 Associated Mucormycosis: Present Status and Future Perspectives.

Authors:  Yasasve Madhavan; Kadambari Vijay Sai; Dilip Kumar Shanmugam; Aashabharathi Manimaran; Karthigadevi Guruviah; Yugal Kishore Mohanta; Divyambika Catakapatri Venugopal; Tapan Kumar Mohanta; Nanaocha Sharma; Saravanan Muthupandian
Journal:  J Clin Med       Date:  2022-06-23       Impact factor: 4.964

2.  Zinc Chelator N,N,N',N'-Tetrakis(2-Pyridylmethyl)Ethylenediamine Reduces the Resistance of Mycobacterium abscessus to Imipenem.

Authors:  Siyuan He; Yuzhen Zou; Mengling Zhan; Qi Guo; Yongjie Zhang; Zhemin Zhang; Bing Li; Shaoyan Zhang; Haiqing Chu
Journal:  Infect Drug Resist       Date:  2020-08-18       Impact factor: 4.003

3.  Estimation of Serum Levels of Heavy Metals in Patients with Chronic Invasive Fungal Rhinosinusitis Before the COVID-19 Era: A Pilot Study.

Authors:  Smile Kajal; Javed Ahsan Quadri; Prankur Verma; Ramya Thota; Kapil Sikka; Shivam Pandey; Alok Thakar; Hitesh Verma
Journal:  Turk Arch Otorhinolaryngol       Date:  2022-05-12

4.  Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans.

Authors:  Ximeng Duan; Zhiyu Xie; Liying Ma; Xueyang Jin; Ming Zhang; Yuliang Xu; Yue Liu; Hongxiang Lou; Wenqiang Chang
Journal:  Microbiol Spectr       Date:  2022-04-18

5.  Mucormycosis in COVID-19: Is Zinc a Silent Killer in India?

Authors:  Sayan Nath; Dalim K Baidya
Journal:  Indian J Crit Care Med       Date:  2021-09

6.  Role of Zinc and Clinicopathological Factors for COVID-19-Associated Mucormycosis (CAM) in a Rural Hospital of Central India: A Case-Control Study.

Authors:  Sunil Kumar; Sourya Acharya; Shraddha Jain; Samarth Shukla; Dhruv Talwar; Divit Shah; Vidyashree Hulkoti; Sana Parveen; Mansi Patel; Sujal Patel
Journal:  Cureus       Date:  2022-02-23

Review 7.  COVID-19-associated mucormycosis of head-and-neck region: A systematic review.

Authors:  Mamata Kamat; Uma Datar; Sanjay Byakodi; Sharad Kamat; Varsha Vimal Kumar
Journal:  J Clin Transl Res       Date:  2022-01-03

8.  New-onset hyperglycaemia and prolonged systemic corticosteroids therapy in mild COVID-19 patients as major risk factors for invasive mucormycosis: a preliminary study.

Authors:  Satyendra Khichar; Subhashree Samantaray; Deepak Kumar; Veena Mobarsa; Vidhi Jain; Vidhu Sharma; Kapil Soni; Bikram Choudhury; Amit Goyal; Durga Shankar Meena; Srikanth Srinivasan; Naveen Dutt; Pankaj Bhardwaj; Ashwini Agarwal; Mahendra Kumar Garg; Sanjeev Misra
Journal:  Curr Med Mycol       Date:  2021-09

Review 9.  Mucormycosis in the COVID-19 Environment: A Multifaceted Complication.

Authors:  Rohit Sharma; Praveen Kumar; Abdur Rauf; Ashun Chaudhary; Pradeep Kumar Prajapati; Talha Bin Emran; Clara Mariana Gonçalves Lima; Carlos Adam Conte-Junior
Journal:  Front Cell Infect Microbiol       Date:  2022-07-18       Impact factor: 6.073

Review 10.  Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread.

Authors:  Shreya Dogra; Akanksha Arora; Aashni Aggarwal; Gautam Passi; Akanksha Sharma; Gurpal Singh; Ravi P Barnwal
Journal:  Front Microbiol       Date:  2022-01-04       Impact factor: 5.640
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