| Literature DB >> 30883342 |
Shanmei Du1,1, Wei Hu2,3,1, Yi Zhao4, Hengzhong Zhou1, Wei Wen1, Miao Xu5, Peiqing Zhao6, Kui Liu3,6.
Abstract
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.Entities:
Keywords: PTEN; breast cancer; invasion; lncRNA MAGI2-AS3; miR-374a; migration
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Year: 2019 PMID： 30883342 DOI： 10.3233/CBM-182216
Source DB: PubMed Journal: Cancer Biomark ISSN： 1574-0153 Impact factor: 4.388