Frank M Biro1,2, Bin Huang2,3, Donald Walt Chandler4, Cecily L Fassler5, Susan M Pinney5. 1. Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. 3. Division of Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 4. Endocrine Sciences, LabCorp, Calabasas Hills, California. 5. Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Abstract
CONTEXT: There is a 4- to 5-year variation in age of breast maturation in girls. OBJECTIVE: To examine longitudinal changes in sex hormone values relative to chronologic age and time relative to breast maturation. SETTING AND DESIGN: Longitudinal observational study into which girls were recruited at 6 to 7 years of age and followed up every 6 months. MAIN OUTCOME MEASURES: Maturation status, chronologic age, race, and fasting blood specimen data were obtained. Hormones were analyzed at 6-month intervals between 2 years before and 1 year after breast maturation, using HPLC tandem mass spectroscopy. RESULTS: Estradiol and estrone levels correlated with chronologic age (R = 0.350 and 0.444, respectively); time was correlated relative to breast maturation (R = 0.222 and 0.323, respectively; all correlations, P < 0.0001). In generalized estimating equation (GEE) models, chronologic age and time relative to pubertal onset were significantly associated with serum estradiol, with similar results for estrone. Local estimated scatterplot smoothing for estradiol and estrone, by chronologic age, demonstrated differences between black and white girls, especially between 8.5 and 11 years of age, but not by race in time relative to breast maturation. Testosterone level was correlated to chronologic age (R = 0.362) and time relative to breast maturation (R = 0.259); in the GEE model, only chronologic age was significant. CONCLUSION: Chronologic age as well as time relative to onset of puberty provided unique information regarding estradiol and estrone concentrations in peripubertal girls. Serum estrogen concentrations should be evaluated with reference to chronologic age and race.
CONTEXT: There is a 4- to 5-year variation in age of breast maturation in girls. OBJECTIVE: To examine longitudinal changes in sex hormone values relative to chronologic age and time relative to breast maturation. SETTING AND DESIGN: Longitudinal observational study into which girls were recruited at 6 to 7 years of age and followed up every 6 months. MAIN OUTCOME MEASURES: Maturation status, chronologic age, race, and fasting blood specimen data were obtained. Hormones were analyzed at 6-month intervals between 2 years before and 1 year after breast maturation, using HPLC tandem mass spectroscopy. RESULTS:Estradiol and estrone levels correlated with chronologic age (R = 0.350 and 0.444, respectively); time was correlated relative to breast maturation (R = 0.222 and 0.323, respectively; all correlations, P < 0.0001). In generalized estimating equation (GEE) models, chronologic age and time relative to pubertal onset were significantly associated with serum estradiol, with similar results for estrone. Local estimated scatterplot smoothing for estradiol and estrone, by chronologic age, demonstrated differences between black and white girls, especially between 8.5 and 11 years of age, but not by race in time relative to breast maturation. Testosterone level was correlated to chronologic age (R = 0.362) and time relative to breast maturation (R = 0.259); in the GEE model, only chronologic age was significant. CONCLUSION: Chronologic age as well as time relative to onset of puberty provided unique information regarding estradiol and estrone concentrations in peripubertal girls. Serum estrogen concentrations should be evaluated with reference to chronologic age and race.
Authors: Frank M Biro; Susan M Pinney; Bin Huang; Erin R Baker; Donald Walt Chandler; Lorah D Dorn Journal: J Clin Endocrinol Metab Date: 2014-07-16 Impact factor: 5.958
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Authors: Frank M Biro; Ashley Pajak; Mary S Wolff; Susan M Pinney; Gayle C Windham; Maida P Galvez; Louise C Greenspan; Larry H Kushi; Susan L Teitelbaum Journal: J Pediatr Adolesc Gynecol Date: 2018-05-24 Impact factor: 1.814
Authors: Frank M Biro; Louise C Greenspan; Maida P Galvez; Susan M Pinney; Susan Teitelbaum; Gayle C Windham; Julianna Deardorff; Robert L Herrick; Paul A Succop; Robert A Hiatt; Lawrence H Kushi; Mary S Wolff Journal: Pediatrics Date: 2013-11-04 Impact factor: 7.124
Authors: Gurmeet K S Singh; Ben W R Balzer; Patrick J Kelly; Karen Paxton; Catherine I Hawke; David J Handelsman; Katharine S Steinbeck Journal: PLoS One Date: 2015-11-23 Impact factor: 3.240
Authors: Mandy Goldberg; Anna J Ciesielski Jones; John A McGrath; Christie Barker-Cummings; Deborah S Cousins; Lauren M Kipling; Juliana W Meadows; James S Kesner; Michele Marcus; Carolyn Monteilh; Dale P Sandler Journal: PLoS One Date: 2021-05-13 Impact factor: 3.240