| Literature DB >> 3088240 |
I Matsuda, Y Ohtani, N Ninomiya.
Abstract
Free and acylcarnitine in serum and urine samples were measured in five patients with hyperammonemia associated with anticonvulsant therapy including sodium valproate, of whom three had a Reye-like syndrome. All had considerable reduction in serum free carnitine and slight increase of acylcarnitine concentrations, suggesting increased conversion of free to acylcarnitine by valproate administration. Urinary excretion of both free and acylcarnitine was increased, accompanied by depressed reabsorption of free carnitine and decreased acylcarnitine/free carnitine clearance ratio. These results indicate a decreased threshold for free carnitine. The combination of these several factors may be responsible for carnitine deficiency in patients with hyperammonemia taking valproate.Entities:
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Year: 1986 PMID： 3088240 DOI： 10.1016/s0022-3476(86)80592-3
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406