| Literature DB >> 3088201 |
S H Kaufmann, E Hug, G De Libero.
Abstract
Lyt-2+ T cell clones were established from Listeria monocytogenes-infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a role for specific cytotoxic T cells in the immune response to intracellular bacteria.Entities:
Mesh:
Substances:
Year: 1986 PMID: 3088201 PMCID: PMC2188209 DOI: 10.1084/jem.164.1.363
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307